지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 342 - 348 (7page)
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초록· 키워드
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Purpose: The goal of this study is to investigate the effects of androgen deprivation therapy (ADT) on total prostate volume and lower urinary tract symptoms (LUTS).
Methods: Between January 2007 and June 2014, 110 patients who received androgen deprivation treatment were enrolled in this retrospective study. Clinical parameters and urodynamic parameters along with changes at follow-up were analyzed. Factors such as reduction in prostate volume, changes in LUTS, and prostate volume tertiles were compared 1 year after ADT.
Results: After ADT, the total International Prostate Symptom Score (IPSS) score decreased from 17.45 to 12.21 and the IPSS voiding subscore decreased from 9.16 to 6.24. Maximal uroflow rate increased from 8.62 to 11.50 mL/sec and residual urine also reduced significantly by 29.34 mL. Change in prostate size was more prominent (?51.14%) in the patients with less than 1 year of ADT (n=21) than those who had more than 1 year of treatment (n=89, ?44.12%). The decrease in the IPSS voiding subscore was greater within 1 year of ADT than after 1 year of treatment (?4.10 vs. ?2.65). The differences were more significant in the 30?50 g group (n=59) and >50 g group (n=11) than the <30 g group (n=40) of the IPSS voiding subscore improvement (?3.76 , ?4.91 vs. ?2.10), and maximal uroflow rate improvement (2.78, 2.90 vs 1.49).
Conclusion: ADT resulted in statistically significant clinical improvement in terms of prostate volume, urodynamic parameters, and LUTS for patients with prostate cancer when analyzed by ADT duration and prostate volume.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Labrie F / 2005 / Gonadotropin-releasing hormone agonists in the treatment of prostate cancer / Endocr Rev 26:361~379
Sanghani MV / 2003 / Quantifying the change in endorectal magnetic resonance imaging-defined tumor volume during neoadjuvant androgen deprivationtherapy in patients with prostate cancer / Urology 62(3 Suppl):487~491
McConnell JD / 2003 / The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia / N Engl J Med 349:2387~2398
조강준 / 2011 / Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia / International Neurourology Journal 15(3):152~157
Hamilton W / 2004 / Symptomatic diagnosis of prostate cancer in primary care: a structured review / Br J Gen Pract 54:617~621
Sanghani MV / 2003 / Quantifying the change in endorectal magnetic resonance imaging-defined tumor volume during neoadjuvant androgen deprivationtherapy in patients with prostate cancer / Urology 62(3 Suppl):487~491
McConnell JD / 2003 / The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia / N Engl J Med 349:2387~2398
조강준 / 2011 / Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia / International Neurourology Journal 15(3):152~157
Hamilton W / 2004 / Symptomatic diagnosis of prostate cancer in primary care: a structured review / Br J Gen Pract 54:617~621
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