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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 589 - 595 (7page)
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초록· 키워드
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Chronic hepatitis B (CHB) infection leads to clinically heterogeneous disease outcomes. Different viral markers are utilized to monitor treatment effects and predict risk of complications in patients with CHB. Hepatitis B core-related antigen (HBcrAg) is a novel serum composite viral protein whose performance has been proven to be superior to that of existing viral markers. It showed good correlation with intrahepatic covalently closed-circular DNA. Its profile differs drastically in patients in different disease phases, and the level declines with antiviral therapies. HBcrAg may be helpful for predicting hepatocellular carcinoma development and hepatitis B virus (HBV) reactivation in immunosuppressed patients. Another emerging measurable serum marker, HBV RNA, exists in the form of pregenomic RNA-containing virions. Its profile differs between patients in different disease phases in a similar manner to that of HBcrAg. HBV RNA is present in serum at lower levels than HBV DNA in treatment-naïve patients by 1–2 logs. In contrast, its level is higher than HBV DNA in patients receiving nucleos(t)ide analogues (NAs). A significant decline in serum RNA was observed in patients receiving novel antiviral therapies, including core protein allosteric modulators and RIG-1/NOD2 agonists. Both HBcrAg and HBV RNA may be helpful for predicting off-therapy sustained virological control in patients who stop long-term NA treatment.
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참고문헌 (48)
참고문헌 신청
Yuen MF / 2018 / Hepatitis B virus infection / Nat Rev Dis Primers 4:18035
Lai CL / 2007 / The natural history and treatment of chronic hepatitis B : a critical evaluation of standard treatment criteria and end points / Ann Intern Med 147:58~61
European Association for the Study of the Liver / 2017 / EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection / J Hepatol 67:370~398
Zoulim F / 2005 / New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA / J Hepatol 42:302~308
Mason AL / 1998 / Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen / Hepatology 27:1736~1742
Lai CL / 2007 / The natural history and treatment of chronic hepatitis B : a critical evaluation of standard treatment criteria and end points / Ann Intern Med 147:58~61
European Association for the Study of the Liver / 2017 / EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection / J Hepatol 67:370~398
Zoulim F / 2005 / New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA / J Hepatol 42:302~308
Mason AL / 1998 / Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen / Hepatology 27:1736~1742
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