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학술저널
저자정보
Kim, Na-Young (Institute of Molecular Biology and Genetics and Department of Molecular Biology, College of Natural Sciences, Seoul National University) Sohn, HeK-wang (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) Choe, Joon-Ho (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) Park, Sang-Dai (Institute of Molecular Biology and Genetics and Department of Molecular Biology, College of Natural Sciences, Seoul National University) Seong, Rho-Hyun (Institute of Molecular Biology and Genetics and Department of Molecular Biology, College of Natural Sciences, Seoul National University)
저널정보
한국통합생물학회 Korean journal of biological sciences Korean journal of biological sciences 제3권 제3호
발행연도
1999.1
수록면
337 - 341 (5page)

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Hepatitis C virus (HCV) is a positive strand RNA virus of the Flaviviridae family and the major cause of post-transfusion non-A, non-B hepatitis. Vaccine development for HCV is essential but has been slowed by poor understanding of the type of immunity that naturally terminates HCV infection. The DNA-based immunization technique offers the potential advantage of including cellular immune responses against conserved internal proteins of a virus, as well as the generation of antibodies to viral surface proteins. Here, we demonstrate that cell lines expressing the HCV core and/or NS3 proteins can induce a specific CTL response in mice, and these results suggest a possibility that the HCV core and NS3 DNA can be used to induce CTL activity against the antigen in mice and can be further developed as a therapeutic and preventive DNA vaccine.

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