지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Physicochemical properties for the inclusion complex of chenodeoxycholic acid(CDCA) and it's $7{\beta}-hydroxy$ epimer ursodeoxycholic acid(UDCA) with ${\beta}-cyclodextrin({\beta}-CyD)$ were studied. The formation of the complex in the solid state were confimed by polarized microscopy and differential scanning calorimetry(DSC). Proton nuclear magnetic resonance$(^1H-NMR)$spectroscopy showed that CDCA and UDCA form an inclusion complex with ${\beta}-CyD$ in aqueous solution. The 1 : 1 stoichiometry of the complex was dextermined by the continuous variation method. From DSC and $^1H-NMR$ studies, there were not any differences between CDCA and UDCA. Complex of CDCA and UDCA showed increase in solubility and dissolution compared with CDCA and UDCA alone, respectively. Solubility pattern of UDCA complex was pH independent but, CDCA complex was like that of CDCA. Dissolution rate increased markedly in case of UDCA complex compared with CDCA complex, especially in acidic pH value.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
우르소데옥시콜린산 및 이의 베타-시클로덱스트린 포접복합체간의 in-vitro 용출, in-vivo 흡수및 이담효과의 비교
약학회지
1994 .01
-
Efficacy of Magnesium Trihydrate of Ursodeoxycholic Acid and Chenodeoxycholic Acid for Gallstone Dissolution: A Prospective Multicenter Trial
Gut and Liver
2015 .01
-
Therapeutic Effect of Whole Bear Bile and Its Components against Croton Oil-Induced Rectal Inflammation in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
Effect of Synthetic Bile Acid Derivatives on the Cell Cycle Modulation of HT -29 Human Colon Cancer Cells
대한약학회 학술대회
2002 .01
-
Ursodeoxycholic Acid Inhibits Pro-Inflammatory Repertoires, $IL-1{\beta}$ and Nitric Oxide in Rat Microglia
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Effects of cholane compounds on the development of morphine tolerance
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
간 보호제 및 담즙산류들이 마크로파지 세포주에서 TNF-${\alpha}$ 분비에 미치는 효과
약학회지
1998 .01
-
Chenodeoxycholic Acid에 의한 파골전구세포의 증식 조절
약학회지
2014 .01
-
Anti-Inflammatory Effect on Rat Microglia by UDCA
대한약학회 학술대회
2003 .01
-
Ursodeoxycholic acid의 무정형 초미립자제제들의 CC 유도 간손상 생쥐에 대한 보호 효과
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2002 .01
-
난용성 의약품의 생체이용률 증진을 위한 무정형 초미립자의 조제 : UDCA와 SLS의 혼합분쇄 효과
약학회지
2002 .01
-
Synthetic Chenodeoxycholic Acid Derivative HS-1200-Induced Apoptosis of Human Oral Squamous Carcinoma Cells
Journal of Oral Medicine and Pain
2007 .09
-
Synthetic Chenodeoxycholic Acid Derivative HS-1200-induced Apoptosis of Human Melanoma Cells
해부·생물인류학
2007 .12
-
Synthetic CDCA Derivatives-Induced Apoptosis of Stomach Cancer Cell Line SNU-1 Cells
Cancer Research and Treatment
2004 .01
-
Ursodeoxycholic Acid Inhibits Inflammatory Cytokine Expression in THP-1 Cells Infected with Aggregatibacter actinomycetemcomitans
International Journal of Oral Biology
2017 .01
-
담즙산류과 베타-사이클로덱스트린간의 복합체 형성
약학회지
1994 .01
-
클로로프로파미드와 싸이클로덱스트린과의 포접 화합물에 관한 연구
약학회지
1986 .01
-
Pretreatment with Ursodeoxycholic Acid (UDCA) as a Novel Pharmacological Intervention in Hepatobiliary Scintigraphy
Yonsei Medical Journal
2005 .01
-
Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
Immune Network
2014 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0