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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제20권 제6호
- 발행연도
- 1997.1
- 수록면
- 525 - 528 (4page)
이용수
초록· 키워드
오류제보하기
Steroid $9{\alpha}$.-hydroxylase is a key enzyme system in steroid nucleus degradation in company with ${\Delta}$-dehydrogenase. To examine $9{\alpha}$-hydroxylase activity during microbial transformation of steroids, 9(11)-dehydro-$17{\alpha}$-methyl-testosterone was adopted as a stable substrate for preventing the rupture of steroid nucleus. Using Nocardia restrictus ATCC 14887 capable of introducing a $9{\alpha}$-hydroxyl group into steroids, $9{\alpha}$,$11{\alpha}$-oxido-$17{\beta}$-hydroxy-$17{\alpha}$-methyl-4-androstene-3-one and $9{\alpha}$-hydroxyl group into steroids,$9{\alpha}$,$11{\alpha}$-oxido-$17{\beta}$-hydroxy-$17{\alpha}$-methyl-1,4-androstadiene-3- one were obtained. These microbiologically transformed products could be used as reference compounds in the enzyme assay.
#Steroid $9{alpha}$-hydroxylase
#9
#11)-Dehydro- $17{alpha}$-methyl-tsetosterone
#$9{alpha}$
#$11{alpha}$-Oxido- $17{beta}$-hydroxy- $17{alpha}$-methyl-4-androstadiene-3-one
#$9{alpha}$
#$11{alpha}$-Oxido- $17{beta}$-hydroxy- $17{alpha}$-methy-1
#4-androstadiene-3-one
#11a-Oxi, 17b-hydroxy-17a-methyl-4-androstene-3-one
목차
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