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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Yong-Seok (Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute) Yi, Young-Suk (Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute) Choi, Shin-Geon (Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute) Kim, Seong-Jin (Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제22권 제1호
발행연도
1999.1
수록면
1 - 8 (8page)

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Transforming growth factor-$\beta$ (TGF-$\beta$) is the prototypical multifunctional cytokine, participating in the regulation of vital cellular activities such as proliferation and differentiations as well as a number of basic physiological functions. The effects of TGF-$\beta$ are critically dependent on the expression and distribution of a family of TGF-$\beta$ receptors, the TGF-$\beta$ types I, II, and III. It is now known that a wide variety of human pathology can be caused by aberrant expression and function of these receptors. the coding sequence of the type II receptor (RII) appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. By virtue of its key role in the regulation of cell proliferation, TGF-$\beta$ RII should be considered as a tumor suppressor gene. High levels of mutation in the TGF-$\beta$ RII gene have been observed in a wide range of primarily epithelial malignancies, including colon and gastric cancer. It appears likely that mutation of the TGF-$\beta$ RII gene may be a very critical step in the pathway of carcinogenesis.

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