지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제11권 제3호
- 발행연도
- 2003.1
- 수록면
- 174 - 177 (4page)
이용수
초록· 키워드
오류제보하기
The present experiment was performed to investigate the protective effects of paeonol isolated from Moutan Cortex Radicis on primary cultured rat hepatocytes exposed to Br-A23187 ($Ca^{2+}$ ionophore). Br-A23187 is frequently used as a model of cell killing as inducing both necrotic and apoptotic cell death. Hepatocytes were isolated by collagenase perfusion from livers of fasted male Sprague Dawley rats and cultured overnight. Cell viability was determined by propidium iodide using fluorocytometry in Krebs-Ringer-HEPES buffer at pH 7.4. In addition, intracellular calcium was measured by excitation at 340 and 380 nm and emission at 505 nm using a luminescence spectrophotometer. Paeonol (20-100 ${\mu}M$) inhibited cell killing induced by 10 ${\mu}M$ Br-A23187, in a dose-dependent manner. Paeonol also reduced increased intracellular calcium level when hepatocytes were exposed to Br-A23187. Therefore, the present results suggest that paeonol protects the hepatocytotoxicity induced by Br-A23187, via inhibiting the influx of calcium into into rat hepatocytes.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protective effects of paeonol on cultured rat hepatocytes exposed to Br-A23187
대한약학회 학술대회
2001 .01
-
Protective effects of paeonol on cultured rat hepatocytes exposed to chemical toxicants.
대한약학회 학술대회
2002 .01
-
Paeonol의 잠재적인 항부정맥 효과의 컴퓨터 시뮬레이션 연구
동의생리병리학회지
2015 .01
-
Paeonol의 잠재적인 항부정맥 효과의 컴퓨터 시뮬레이션 연구
동의생리병리학회지
2015 .08
-
Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
CYTOTOXICITY OF T-2 TOXIN ON PRIMARY CULTURES OF RAT HEPATOCYTES
한국독성학회지
1988 .06
-
Inhibitory Effects of Paeonol on Morphine-Induced Locomotor Sensitization and Conditioned Place Preference in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Antiallergic Effect of the Root of Paeonia lactiflora and Its Constituents Paeoniflorin and Paeonol
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Anti-tumor effects of paeonol oxime through inhibition of metastasis and angiogenesis
대한동의병리학회 학술대회논문집
2006 .09
-
Three-dimensional (3D) printing of mouse primary hepatocytes to generate 3D hepatic structure
Annals of Surgical Treatment and Research
2017 .02
-
Hepatocytes Transplantation
한국간담췌외과학회 학술대회지
2005 .03
-
Primary Culture of Human Hepatocytes from Small Size Sample
한국독성학회지
1992 .12
-
Effects of glucose concentration in the medium on rat hepatocyte culture
Annals of Surgical Treatment and Research
2014 .07
-
CYTOTOXICITY OF D-GALACTOSAMINE ON PRIMARY CULTURES OF ADULT RAT HEPATOCYTES
한국독성학회지
1987 .12
-
Paeonol에 의한 표피줄기세포 활성화
대한화장품학회지
2016 .01
-
간세포이식을 통한 간질환 극복과 유전자 치료의 가능성
Clinical and Experimental Pediatrics
2002 .01
-
Successful mouse hepatocyte culture with sandwich collagen gel formation
Annals of Surgical Treatment and Research
2013 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0