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논문 기본 정보

자료유형
학술저널
저자정보
Park, Yun Soo (Department of Nuclear Medicine, Busan Paik Hospital, University of Inje College of Medicine) Lee, Seok Mo (Department of Nuclear Medicine, Busan Paik Hospital, University of Inje College of Medicine) Park, Ji Sun (Department of Nuclear Medicine, Busan Paik Hospital, University of Inje College of Medicine) Bae, Sang Kyun (Department of Nuclear Medicine, Haundae Paik Hospital, University of Inje College of Medicine) Shim, Hye-Kyung (Department of Nuclear Medicine, Haundae Paik Hospital, University of Inje College of Medicine) Lee, Won-Sik (Department of Internal Medicine, Busan Paik Hospital, University of Inje College of Medicine) Lee, Sang-Min (Department of Internal Medicine, Busan Paik Hospital, University of Inje College of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제52권 제3호
발행연도
2018.1
수록면
216 - 223 (8page)

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Objectives This study aimed to determine the value of clinical prognostic factors and semiquantitative metabolic parameters from initial staging fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in non-Hodgkin lymphoma (NHL) patients treated with stem cell transplantation (SCT). Methods A total of 39 malignant lymphoma patients who underwent initial staging F-18 FDG PET/CT were enrolled in this study. SUVmax, MTV_wb, and TLG_wb were measured during the initial staging PET/CT. Receiver operating characteristic curve (ROC) analysis was adopted to dichotomize continuous variables. Log-rank test and Cox proportional hazard regression analysis were used to evaluate diseasefree survival (DFS) rate. Results Among the 39 patients with malignant lymphoma, 17 (43.6%) had a relapse. For several clinical factors such as age, ECOG performance score, AMC/ALC score, stages, and revised International Prognostic Index score, differences between the two dichotomized groups were statistically insignificant. In univariate analysis, DFS estimates were $71.0{\pm}7.8months$ and $18.0{\pm}5.9months$ in high-SUVmax and low-SUVmax group, respectively (P < 0.01). For MTV_wb, DFS estimates were $46.6{\pm}12.4months$ and $69.1{\pm8.5months$ in high-MTV_wb and low-MTV_wb group, respectively (P = 0.12). For TLG_wb, DFS estimates were $65.3{\pm}7.5months$ and $13.7{\pm}8.6months$ in high-TLG_wb and low-TLG_wb group, respectively (P = 0.02). In Cox proportional hazard regression analysis, only MTV_wb showed statistical significance (HR 3.01, 95% CI 1.04-8.74, P = 0.04). Conclusion In NHL patients treated with SCT, the MTV_wb of initial staging F-18 FDG PET/CT was an independent prognostic factor.

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