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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 45 - 57 (13page)
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In the neurovascular unit, the neuronal and vascular systems communicate with each other. O2 and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into neighboring cells, such as neural stem cells, and neurons. The proper function of neural circuits in adults requires sufficient O2 and glucose for their metabolic demands through angiogenesis. In a central nervous system (CNS) injury, such as glioma, Parkinson's disease, and Alzheimer's disease, damaged ECs can contribute to tissue hypoxia and to the consequent disruption of neuronal functions and accelerated neurodegeneration. This review discusses the current evidence regarding the contribution of oxygen deprivation to CNS injury, with an emphasis on hypoxia-inducible factor (HIF)-mediated pathways and Notch signaling. Additionally, it focuses on adult neurological functions and angiogenesis, as well as pathological conditions in the CNS. Furthermore, the functional interplay between HIFs and Notch is demonstrated in pathophysiological conditions.
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참고문헌 (159)
참고문헌 신청
Ables, J. L. / 2011 / Not(ch)just development : Notch signalling in the adult brain / Nat. Rev. Neurosci 12:269~283
Andreu-Agullo, C. / 2009 / Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone / Nat. Neurosci 12:1514~1523
Androutsellis-Theotokis, A. / 2006 / Notch signalling regulates stem cell numbers in vitro and in vivo / Nature 442:823~826
Ashok, B. S. / 2017 / Hypoxia-inducible factors as neuroprotective agent in Alzheimer’s disease / Clin. Exp. Pharmacol. Physiol 44:327~334
Austin, C. P. / 1995 / Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch / Development 121:3637~3650
Andreu-Agullo, C. / 2009 / Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone / Nat. Neurosci 12:1514~1523
Androutsellis-Theotokis, A. / 2006 / Notch signalling regulates stem cell numbers in vitro and in vivo / Nature 442:823~826
Ashok, B. S. / 2017 / Hypoxia-inducible factors as neuroprotective agent in Alzheimer’s disease / Clin. Exp. Pharmacol. Physiol 44:327~334
Austin, C. P. / 1995 / Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch / Development 121:3637~3650
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