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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 433 - 442 (10page)
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The biological effects of nano- and micro-sized $Al_2O_3$ particles are hypothesized to differ according to the shapes as well as the sizes of the particles. Thus, the mechanisms of interleukin (IL)-$1{\beta}$ production and the association between the shape of the $Al_2O_3$ particle and its cytotoxicity in macrophage-like THP-1 cells were investigated using particles with three different shapes [$N-Al_2O_3$ (<30 nm), $S-Al_2O_3$ ($2-4nm{\times}100-800nm$), $L-Al_2O_3$ ($2-4nm{\times}2800nm$)]. Levels of IL-$1{\beta}$ production and cytotoxicity were concentration-dependent and were in the following order: $S-Al_2O_3$ > $N-Al_2O_3$ > $L-Al_2O_3$. Stimulus of THP-1 cells by $Al_2O_3$ particles led to lysosomal destabilization, generation of intracellular reactive oxygen species (ROS), and subsequent release of cathepsin B. The magnitude of the stimulus was dependent on the shapes and aspect ratios of the particles. Additional results suggested that caspase-1 (NALP3 inflammasome) activation and IL-$1{\beta}$ production followed cathepsin B release. In addition, the cell death induced by $Al_2O_3$ particles was closely related with cathepsin B leakage. The mode of cell death was necrotic as much as apoptotic. We conclude that $Al_2O_3$ particles induce different levels of IL-$1{\beta}$ production and cytotoxicity depending on their particle shapes or aspect ratios. The current finding may support the development of safe forms of $Al_2O_3$ particles.
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