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자료유형
학술저널
저자정보
Park, Mi-Kyung (College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University) Rhyu, Mee-Ra (Food Function Research Division, Korea Food Research Institute) Yoon, Byung-Koo (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Kwon, Hyeok-Yi (College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University) Jang, Si-Youl (School of Engineering Kookmin University) Lee, Young-Joo (College of Engineering, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제2호
발행연도
2008.1
수록면
225 - 230 (6page)

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We investigated the estrogenic activity of Cirsium japonicum water extracts, which have long been used to treat vascular-related diseases. The activity of the extracts was characterized in a transient transfection system, using estrogen receptor isoforms and estrogen-responsive luciferase plasmids in HEK 293 cells. The extract activated both and estrogen receptors. Activation was inhibited by the estrogen receptor antagonist ICI182,780 indicating that the effects were mediated through the estrogen receptor isoforms. Treatment with the extracts increased expression of the progesterone receptor and pS2 genes and expression of estrogen receptor was decreased in MCF-7 cells. These results suggested that the cirsium japonicum water extracts showed estrogenic effects and may be a potential clinical application for treatment of estrogen related vascular diseases.

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