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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The antibody-drug conjugate (ADC) is one of the most rapidly growing next generation antibody therapies used in oncology, autoimmunity and chronic inflammatory diseases. ADC is consisted of monoclonal antibody conjugated via chemical linker with highly cytotoxic small molecules, called payloads. Due to the rising prevalence of cancer and population aging, there is a consistent unmet needs on novel therapeutics for patients where the traditional antibody therapy does not work. With the successful market settlement of FDA-approved Adcetris(R) and Kadcyla(R), global pharmaceutical companies have put their resources for development of this innovative drug class. There are still some drawbacks in this class of drug including linker stability and heterogenous drug antibody ratio (DAR) profile. However new platform technologies are making progress to overcome these problems and further investment will drive growth in the next generation antibody therapies market. In this manuscript, we review the market drivers and restraints and introduce four approved ADCs. We then mainly discuss the important aspects considered while developing ADCs (cytotoxic drug, linker, DAR) and ADC platforms widely used in the industries.
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참고문헌 (35)
참고문헌 신청
2016 / Next-generation antibody therapies market forecast
Hoffmann, R. M. / 2018 / Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs) / Oncoimmunology 7:e1395127
Jain, N. / 2015 / Current ADC Linker Chemistry / Pharm Res 32:3526
Gromek, S. M. / 2015 / Natural products as exquisitely potent cytotoxic payloads for antibody- drug conjugates / Curr Top Med Chem 14:2822
Masters, J. C. / 2018 / Clinical toxicity of antibody drug conjugates: a meta-analysis of payloads / Invest New Drugs 36:121
Hoffmann, R. M. / 2018 / Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs) / Oncoimmunology 7:e1395127
Jain, N. / 2015 / Current ADC Linker Chemistry / Pharm Res 32:3526
Gromek, S. M. / 2015 / Natural products as exquisitely potent cytotoxic payloads for antibody- drug conjugates / Curr Top Med Chem 14:2822
Masters, J. C. / 2018 / Clinical toxicity of antibody drug conjugates: a meta-analysis of payloads / Invest New Drugs 36:121
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