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논문 기본 정보

자료유형
학술저널
저자정보
Yun Sojeong (Department of Biomedicine) Ryu Ji Hyeong (Department of Laboratory Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Univer) Jang Joo Hee (Department of Biomedicine) Bae Hyunjoo (Department of Biomedicine) Yoo Seung-Hyo (Department of Laboratory Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Univer) Choi Ae-Ran (Department of Laboratory Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Univer) Jo Sung Jin (Department of Laboratory Medicine Eunpyeong St. Mary’s Hospital College of Medicine The Catholic Un) Lim Jihyang (Department of Laboratory Medicine Eunpyeong St. Mary’s Hospital College of Medicine The Catholic Un) Lee Jehoon (Department of Laboratory Medicine Eunpyeong St. Mary’s Hospital College of Medicine The Catholic Un) Ryu Hyejin (Samkwang Medical Laboratories Seoul Korea) Cho Sung-Yeon (Division of Infectious Diseases Department of Internal Medicine Seoul St. Mary’s Hospital College o) Lee Dong-Gun (Division of Infectious Diseases Department of Internal Medicine Seoul St. Mary’s Hospital College o) Lee Jongmin (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Seoul St.) Kim Seok Chan (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Seoul St.) Park Yeon-Joon (Department of Laboratory Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Univer) Lee Hyeyoung (Department of Laboratory Medicine Catholic Kwandong University International St. Mary’s Hospital In) Oh Eun-Jee (Department of Laboratory Medicine Seoul St. Mary’s Hospital College of Medicine The Catholic Univer)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제6호
발행연도
2021.11
수록면
577 - 587 (11page)
DOI
10.3343/alm.2021.41.6.577

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays have high clinical utility in managing the pandemic. We compared antibody responses and seroconversion of coronavirus disease 2019 (COVID-19) patients using different immunoassays. Methods: We evaluated 12 commercial immunoassays, including three automated chemiluminescent immunoassays (Abbott, Roche, and Siemens), three enzyme immunoassays (Bio-Rad, Euroimmun, and Vircell), five lateral flow immunoassays (Boditech Med, SD biosensor, PCL, Sugentech, and Rapigen), and one surrogate neutralizing antibody assay (GenScript) in sequential samples from 49 COVID-19 patients and 10 seroconversion panels. Results: The positive percent agreement (PPA) of assays for a COVID-19 diagnosis ranged from 84.0% to 98.5% for all samples (>14 days after symptom onset), with IgM or IgA assays showing higher PPAs. Seroconversion responses varied across the assay type and disease severity. Assays targeting the spike or receptor-binding domain protein showed a tendency for early seroconversion detection and higher index values in patients with severe disease. Index values from SARS-CoV-2 binding antibody assays (three automated assays, one LFIA, and three EIAs) showed moderate to strong correlations with the neutralizing antibody percentage (r=0.517?0.874), and stronger correlations in patients with severe disease and in assays targeting spike protein. Agreement among the 12 assays was good (74.3%?96.4%) for detecting IgG or total antibodies. Conclusions: Positivity rates and seroconversion of SARS-CoV-2 antibodies vary depending on the assay kits, disease severity, and antigen target. This study contributes to a better understanding of antibody response in symptomatic COVID-19 patients using currently available assays.
#SARS-CoV-2 antibody #Immunoassays #Neutralizing antibody #Seroconversion #Correlation #Disease severity #Positive percent agreement

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참고문헌 (28)

참고문헌 신청
Wu Z / 2020 / Characteristics of and important lessons from the coronavirus Disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention / JAMA 323:1239~1242 google schola Fong CH / 2020 / Improved detection of antibodies against SARS-CoV-2 by microsphere-based antibody assay / Int J Mol Sci 21:6595 google schola Tu YF / 2020 / A review of SARS-CoV-2 and the ongoing clinical trials / Int J Mol Sci 21:2657 google schola Trabaud MA / 2020 / Comparison of eight commercial, high-throughput, automated or ELISA assays detecting SARS-CoV-2 IgG or total antibody / J Clin Virol 132:104613 google schola Charlton CL / 2020 / Evaluation of six commercial mid- to high-volume antibody and six point-of-care lateral flow assays for detection of SARS-CoV-2 antibodies / J Clin Microbiol 58:e01361-20 google schola

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