만성폐쇄성폐질환을 동반한 광물성분진 노출 이직근로자의 철 결핍

이종성; 신재훈; 백진이; 정지영; 김형근; 최병순

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자료유형: 학술저널

저자정보: 이종성 (근로복지공단 직업환경연구원) 신재훈 (근로복지공단 직업환경연구원) 백진이 (근로복지공단 직업환경연구원) 정지영 (근로복지공단 직업환경연구원) 김형근 (근로복지공단 인천병원) 최병순 (근로복지공단 직업환경연구원)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제29권 제1호

발행연도: 2019.1

수록면: 42 - 49 (8page)

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Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Iron deficiency is associated with chronic inflammation, such as COPD. The aim of this study was to evaluate the relationship among iron deficiency, iron homeostasis, and inflammation in retired miners with COPD. Methods: The serum levels of ferritin, soluble transferrin receptor(sTfR), and transferrin saturation(TSat) as biomarkers for iron deficiency and high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation and hepcidin as a biomarker for iron homeostasis were measured in 93 male subjects. Iron deficiency was defined as any one or more of (1) sTfR>28.1 nmol/L, (2) TSat<16%, and (3) ferritin< $12{\mu}g/L$. Results: Iron deficiency was found 28% of the study subjects. Median levels of serum hsCRP was significantly increased related to airflow limitation of COPD(GOLD 1, $0.09{\mu}g/dL$ vs. GOLD 2, $0.17{\mu}g/dL$ vs. GOLD $3{\leq}$, $0.30{\mu}g/dL$, p=0.010), and was positively correlated with hepcidin(p=0.009). Mean level of serum hepcidin was lower in COPD subjects with iron deficiency(p=0.004) and serum levels of hepcidin was negatively correlated with %$FEV_1$ predicted(p=0.030). Conclusions: These results suggest that high serum levels of hepcidin are related to severe airflow limitation or inflammation and can decrease iron availability, regardless of iron status.

#chronic obstructive pulmonary disease #C-reactive protein #hepcidin #iron deficiency #retired miner

참고문헌 (40)

참고문헌 신청

A. Agusti / 2006 / Thomas A. Neff Lecture. Chronic Obstructive Pulmonary Disease: A Systemic Disease / Proceedings of the American Thoracic Society 3(6):478~481

Ahn J / 1993 / Origin of a soluble truncated transferrin receptor / Blood 81(9):2442~2451

undefined / 2003 / American Thoracic Society Statement: Occupational contribution to the burden of airway disease / American Journal of Respiratory and Critical Care Medicine 167(5):787~797

Yves Beguin / 2003 / Soluble transferrin receptor for the evaluation of erythropoiesis and iron status / Clinica Chimica Acta 329(1-2):9~22

I.A. Bergdahl / 2004 / Increased mortality in COPD among construction workers exposed to inorganic dust / European Respiratory Journal 23(3):402~406

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이종성

소속기관 근로복지공단 직업환경연구원

주요연구분야 의약학 > 기초의학 > 예방의학·직업환경의학 의약학 > 임상의학 > 내과학

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신재훈

소속기관 근로복지공단 직업환경연구원