지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives Dopamine dysregulation has been regarded as one of the core pathologies in patients with schizophrenia. Since dopamine synthesis capacity has found to be inconsistent in patients with schizophrenia, current classification of patients based on clinical symptoms cannot reflect the neurochemical heterogeneity of the disease. Here we performed new subtyping of patients with first-episode psychosis (FEP) through biotype-based cluster analysis. We specifically suggested basal ganglia structural changes as a biotype, which deeply involves in the dopaminergic circuit. Methods Forty FEP and 40 demographically matched healthy participants underwent 3T T1 MRI. Whole brain parcellation was conducted, and volumes of total 6 regions of basal ganglia have been extracted as features for cluster analysis. We used K-means clustering, and external validation was conducted with Positive and Negative Syndrome Scale (PANSS). Results K-means clustering divided 40 FEP subjects into 2 clusters. Cluster 1 (n = 25) showed substantial volume decrease in 4 regions of basal ganglia compared to Cluster 2 (n = 15). Cluster 1 showed higher positive scales of PANSS compared with Cluster 2 (F = 2.333, p = 0.025). Compared to healthy controls, Cluster 1 showed smaller volumes in 4 regions, whereas Cluster 2 showed larger volumes in 3 regions. Conclusions Two subgroups have been found by cluster analysis, which showed a distinct difference in volume patterns of basal ganglia structures and positive symptom severity. The result possibly reflects the neurobiological heterogeneity of schizophrenia. Thus, the current study supports the importance of paradigm shift toward biotype-based diagnosis, instead of phenotype, for future precision psychiatry.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Wiersma D / 2000 / Social disability in schizophrenia: its development and prediction over 15 years in incidence cohorts in six European centres / Psychol Med 30:1155~1167
Snyder SH / 1976 / The dopamine hypothesis of schizophrenia: focus on the dopamine receptor / Am J Psychiatry 133:197~202
Kapur S / 2000 / A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy / Arch Gen Psychiatry 57:553~559
Baron JC / 1989 / Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels / Psychopharmacology (Berl) 99:463~472
Brucke T / 1991 / Dopamine D2 receptor imaging with SPECT: studies in different neuropsychiatric disorders / J Cereb Blood Flow Metab 11:220~228
Snyder SH / 1976 / The dopamine hypothesis of schizophrenia: focus on the dopamine receptor / Am J Psychiatry 133:197~202
Kapur S / 2000 / A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy / Arch Gen Psychiatry 57:553~559
Baron JC / 1989 / Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels / Psychopharmacology (Berl) 99:463~472
Brucke T / 1991 / Dopamine D2 receptor imaging with SPECT: studies in different neuropsychiatric disorders / J Cereb Blood Flow Metab 11:220~228
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genetic Diversity of Metallo-β-lactamase Genes of Chryseobacterium indologenes Isolates from Korea
대한의생명과학회지
2019 .09
-
Brain research with primate model: elucidating the parallel basal ganglia circuits for controlled and habitual behavior
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy
대한뇌졸중학회지
2021 .01
-
기저핵 뇌경색 환자의 편마비 한방치료 1례
혜화의학회지
2018 .01
-
고유수용성신경근촉진법을 사용한 몸통 강화 및 안정화 운동이 기저핵 뇌졸중 환자의 균형과 보행 능력에 미치는 영향
한국신경근육재활학회지
2020 .01
-
항암화학요법을 받는 비호지킨 림프종 환자의 증상클러스터
Asian Oncology Nursing
2022 .06
-
Chorea Hyperglycemia Basal Ganglia Syndrome in a Young Patient with Type 1 Diabetes Mellitus: a Case Report
뇌신경재활
2020 .01
-
Fahr disease가 의심되는 기저핵 석회화 환자에 대한 한방 처치 1례
대한한방내과학회지
2019 .01
-
편마비 및 보행장애를 호소하는 기저핵 뇌경색 환자에 대한 한의 치료 증례보고 1례
대한한방내과학회지
2022 .05
-
Symptom Clusters and Quality of Life in People with Long COVID: A Cross-Sectional Online Survey
기본간호학회지
2024 .08
-
심장판막 수술환자의 회복기간에 따른 증상클러스터와 삶의 질 변화
중환자간호학회지
2019 .01
-
요인 및 군집분석을 이용한 유해화학물질 사고 잠재적 피해에 대한 도시 유형 분류 및 특성 분석
한국환경보건학회지
2020 .12
-
Intraparenchymal Atypical Meningioma in Basal Ganglia Region in a Child : Case Report and Literature Review
대한신경외과학회지
2018 .01
-
Psychopathologic Profiles and Clusters in Tertiary Clinic Referred Patients with Adult Attention Deficit Hyperactivity Disorder: A Person-Centered Analysis
PSYCHIATRY INVESTIGATION
2021 .01
-
Differences Between Positive and Negative Perceptions of Stress Based on Patterns of Coping Strategies: Through Mobile Application in College Students
우울조울병
2024 .07
-
Identification of cranial nerve ganglia using sectioned images and three-dimensional models of a cadaver
The Korean Journal of Pain
2022 .07
-
Movement Disorders Resulting From Bilateral Basal Ganglia Lesions in End-Stage Kidney Disease: A Systematic Review
Journal Of Movement Disorders
2022 .09
-
Predicting Symptomatic and Functional Improvements over 1 Year in Patients with First-Episode Psychosis Using Resting-State Electroencephalography
PSYCHIATRY INVESTIGATION
2019 .01
-
관상동맥질환자의 위험인자 군집유형이 부정적 임상예후에 미치는 영향: 이차분석 연구
성인간호학회지
2020 .04
-
ADHD의 K-CBCL 아동ㆍ청소년 행동평가척도 군집분석: 아동복지시설 아동ㆍ청소년 대상으로
한국놀이치료학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0