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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 695 - 703 (9page)
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초록· 키워드
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Objective Although early intervention from the beginning of a psychotic episode is essential for a better prognosis, biomarkers predictive of symptomatic and functional improvement in early psychotic disorders are lacking. This study aimed to investigate whether the spectral power of resting-state electroencephalography (EEG) can be used as a predictive marker of the 1-year prognosis in patients with first-episode psychosis (FEP). Methods Twenty-four patients with FEP and matched healthy control (HC) subjects were examined with resting-state EEG at baseline. The symptomatic severity and functional status of FEP patients were assessed at baseline and reassessed after 1 year of usual treatment. Repeated measures analysis of variance was conducted to compare EEG spectral powers across the groups. Multiple regression analysis revealed EEG spectral powers predictive of symptomatic and functional improvement in FEP patients at the 1-year follow-up. Results Delta band power in the frontal and posterior regions was significantly higher in patients with FEP than in HCs. Higher delta band power in the posterior region predicted later improvement of positive symptoms and general functional status. Lower delta band power in the frontal region predicted improvement of negative symptoms and general functioning after 1 year. Conclusion These results suggest that increased delta absolute power is observed from the beginning of psychotic disorders. Furthermore, decreased delta power in the frontal region and increased delta power in the posterior region might be used as a predictive marker of a better prognosis of FEP, which would aid early intervention in clinical practice.
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참고문헌 (43)
참고문헌 신청
Suvisaari J / 2018 / Is it possible to predict the future in first-episode psychosis? / Front Psychiatry 9:580
Lieberman JA / 2001 / The early stages of schizophrenia : speculations on pathogenesis, pathophysiology, and therapeutic approaches / Biol Psychiatry 50:884~897
Marshall M / 2005 / Association between duration of untreated psychosis and outcome in cohorts of first-episode patients : a systematic review / Arch Gen Psychiatry 62:975~983
Perkins DO / 2005 / Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia : a critical review and meta-analysis / Am J Psychiatry 162:1785~1804
Staring AB / 2009 / Fewer symptoms vs. more side-effects in schizophrenia? Opposing pathways between antipsychotic medication compliance and quality of life / Schizophr Res 113:27~33
Lieberman JA / 2001 / The early stages of schizophrenia : speculations on pathogenesis, pathophysiology, and therapeutic approaches / Biol Psychiatry 50:884~897
Marshall M / 2005 / Association between duration of untreated psychosis and outcome in cohorts of first-episode patients : a systematic review / Arch Gen Psychiatry 62:975~983
Perkins DO / 2005 / Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia : a critical review and meta-analysis / Am J Psychiatry 162:1785~1804
Staring AB / 2009 / Fewer symptoms vs. more side-effects in schizophrenia? Opposing pathways between antipsychotic medication compliance and quality of life / Schizophr Res 113:27~33
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