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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 177 - 184 (8page)
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The target of rapamycin (TOR) signaling pathway is a conserved pathway that regulates eukaryotic cell growth in response to environmental cues. Chemical genomic approaches that profile rapamycin sensitivity of yeast deletion strains have given insights into the function of TOR signaling pathway. In the present study, we analyzed the rapamycin sensitivity of yeast deletion library strains on synthetic medium. As a result, we identified 130 strains that are hypersensitive or resistant to rapamycin compared with wild-type cells. Among them, 36 genes are newly identified to be related to rapamycin sensitivity. Moreover, we found 16 strains that show alteration in rapamycin sensitivity between complex and synthetic media. We suggest that these genes may be involved in part of TOR signaling activities that is differentially regulated by media composition.
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참고문헌 (34)
참고문헌 신청
Abe, F. / 2008 / Global screening of genes essential for growth in high-pressure and cold environments: searching for basic adaptive strategies using a yeast deletion library / Genetics 178:851~872
Beck, T. / 1999 / The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors / Nature 402:689~692
Carvalho, J. / 2003 / Domains of Gln3p interacting with karyopherins, Ure2p, and the target of rapamycin protein / J. Biol. Chem. 278:16878~16886
Chan, T.F. / 2000 / A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR) / Proc. Natl. Acad. Sci. USA :13227~13232
Di Como, C.J. / 1996 / Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases / Genes Dev. 10:1904~1916
Beck, T. / 1999 / The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors / Nature 402:689~692
Carvalho, J. / 2003 / Domains of Gln3p interacting with karyopherins, Ure2p, and the target of rapamycin protein / J. Biol. Chem. 278:16878~16886
Chan, T.F. / 2000 / A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR) / Proc. Natl. Acad. Sci. USA :13227~13232
Di Como, C.J. / 1996 / Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases / Genes Dev. 10:1904~1916
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