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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 173 - 179 (7page)
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The purpose of this study was to determine whether rapamycin could inhibit corneal angiogenesis induced by basic fibroblast growth factor (bFGF). Using human dermal microvascular endothelial cells (HDMECs), we examined the effect of rapamycin on cell proliferation and migration, and the expression of vascular endothelial growth factor (VEGF). The rabbits eye was implanted intrastromally into the superior cornea with pellet containing bFGF for the control group and pellet containing bFGF and rapamycin for the rapamycin group. Biomicro-graphically, corneal angiogenesis was evaluated for 10 days after pellet implantation. The neovas-cularized cornea also was examined histologically. bFGF induced corneal neovascularization was Using in vitro model, rapamycin strongly inhibited bFGF induced proliferation, migration, and VEGF secretion of HDMECs. We could observe that the bFGF induced corneal angiogenesis was inhibited by rapamycin in a micropocket rabbit model. The score of neovascularization was significantly de-creased in the rapamycin group than in the control group at 10 days after pellet implantation. Histo-logically, the cornea of rapamycin group also showed much less new vessels than that of control group. Collectively, rapamycin appears to inhibit bFGF induced angiogenesis in a rabbit corneal micro-pocket assay and may have therapeutic potential as an antiangiogenic agent.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1977 / Inhibition of the immune response by rapamycin,a new antifungal antibiotic 55 : 48 ~ 51
/ 1978 / In vitro and in vivo evaluation : 539 ~ 22 45
/ 1987 / a unique regulator of blood vessel function : 219 250 ~ 7
/ 1988 / An animal model for corneal graft rejection in high-risk keratoplasty 46 : 26 ~ 30
/ 1990 / Angiogenic growth factors 2 : 71 ~ 9
/ 1978 / In vitro and in vivo evaluation : 539 ~ 22 45
/ 1987 / a unique regulator of blood vessel function : 219 250 ~ 7
/ 1988 / An animal model for corneal graft rejection in high-risk keratoplasty 46 : 26 ~ 30
/ 1990 / Angiogenic growth factors 2 : 71 ~ 9
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