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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 370 - 376 (7page)
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초록· 키워드
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Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-cancer activities. In this study, we examined the regulatory activity of G-Rp1 on the functional activation of macrophages. G-Rp1 remarkably inhibited TNF-$\alpha$ production, LPS-induced cell cytotoxicity, NO production, ROS generation, and phagocytic uptake from lipopolysacchride (LPS)-activated RAW264.7 cells. According to structural feature study using several G-Rp1 analogs, two carbohydrates (glucose-glucose) at R1 position were observedto be highly effective, compared to other structural derivatives. Although the inhibitory activities of G-Rp1 on macrophage functions were not remarkable, several points that G-Rp1 was known to be safe, and that this compound was orally effective, suggest that G-Rp1 may be beneficial in treating macrophage-mediated immunological diseases.
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참고문헌 (26)
참고문헌 신청
Bae, E. A / 2006 / Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/ interferon-gamma-stimulated BV-2 microglial cells / Planta Med 72:627~633
Bai, X. C / 2005 / Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast / J. Biol. Chem 280:17497~17506
Cho, J. Y / 2000 / In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa / Eur. J. Pharmacol 398:399~407
Cho, J. Y / 2001 / The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation / Blood 98:374~382
Cho, J. Y / 2001 / In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists / Planta. Med 67:213~218
Bai, X. C / 2005 / Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast / J. Biol. Chem 280:17497~17506
Cho, J. Y / 2000 / In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa / Eur. J. Pharmacol 398:399~407
Cho, J. Y / 2001 / The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation / Blood 98:374~382
Cho, J. Y / 2001 / In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists / Planta. Med 67:213~218
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