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논문 기본 정보

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학술저널
저자정보
Park, Bo Kyung (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University) Gonzales, Edson Luck T. (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University) Yang, Sung Min (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University) Bang, Minji (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University) Choi, Chang Soon (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University) Shin, Chan Young (Department of Neuroscience, School of Medicine, and Neuroscience Research Center, SMART-IABS and KU Open Innovation Center, Konkuk University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제24권 제1호
발행연도
2016.1
수록면
99 - 107 (9page)

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Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful effects of triclosan in many systemic and cellular processes of the body. In this study, we investigated the effects of triclosan in the survivability of cultured rat neural stem cells (NSCs). Cortical cells from embryonic day 14 rat embryos were isolated and cultured in vitro. After stabilizing the culture, triclosan was introduced to the cells with concentrations ranging from $1{\mu}M$ to $50{\mu}M$ and in varied time periods. Thereafter, cell viability parameters were measured using MTT assay and PI staining. TCS decreased the cell viability of treated NSC in a concentration-dependent manner along with increased expressions of apoptotic markers, cleaved caspase-3 and Bax, while reduced expression of Bcl2. To explore the mechanisms underlying the effects of TCS in NSC, we measured the activation of MAPKs and intracellular ROS. TCS at $50{\mu}M$ induced the activations of both p38 and JNK, which may adversely affect cell survival. In contrast, the activities of ERK, Akt and PI3K, which are positively correlated with cell survival, were inhibited. Moreover, TCS at this concentration augmented the ROS generation in treated NSC and depleted the glutathione activity. Taken together, these results suggest that TCS can induce neurodegenerative effects in developing rat brains through mechanisms involving ROS activation and apoptosis initiation.
#Triclosan #Apoptosis #Oxidation #Rat neural stem cells #MAPK signaling

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참고문헌 (37)

참고문헌 신청
Ahn, K. C / 2008 / In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens / Environ. Health Perspect 116:1203~1210 google schola Aiello, A. E / 2007 / Consumer antibacterial soaps: effective or just risky? / Clin. Infect. Dis 45:s137~s147 google schola Allmyr, M / 2006 / Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products / Sci. Total Environ 372:87~93 google schola Bedoux, G / 2012 / Occurrence and toxicity of antimicrobial triclosan and by-products in the environment / Environ. Sci. Pollut. Res 19:1044~1065 google schola Brausch, J. M / 2011 / A review of personal care products in the aquatic environment: Environmental concentrations and toxicity / Chemosphere 82:1518~1532 google schola

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