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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 503 - 511 (9page)
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초록· 키워드
오류제보하기
Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS ($0.1-10{\mu}M$), BPA ($0.1-10{\mu}M$) and E2 ($0.01-0.0001{\mu}M$) induced significant cell proliferation of VM7Luc4E2 cells, which was restored to the control (0.1% DMSO) by co-treatment with Kaem ($30{\mu}M$) or DIM ($15{\mu}M$). Reactive oxygen species (ROS) production assays showed that TCS and BPA inhibited ROS production of VM7Luc4E2 cells similar to E2, but that co-treatment with Kaem or DIM on VM7Luc4E2 cells induced increased ROS production. Based on these results, the effects of TCS, BPA, Kaem, and DIM on protein expression of apoptosis and ROS production-related markers such as Bax and Bcl-xl, as well as endoplasmic reticulum (ER) stress-related markers such as $eIF2{\alpha}$ and CHOP were investigated by Western blot assay. The results revealed that TCS, and BPA induced anti-apoptosis by reducing ROS production and ER stress. However, Kaem and DIM effectively inhibited TCS and BPA-induced anti-apoptotic processes in VM7Luc4E2 cells. Overall, TCS and BPA were revealed to be distinct xenoestrogens that enhanced proliferation and anti-apoptosis, while Kaem and DIM were identified as natural chemopreventive compounds that effectively inhibited breast cancer cell proliferation and increased anti-apoptosis induced by TCS and BPA.
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등록된 정보가 없습니다.
참고문헌 (55)
참고문헌 신청
Abdelrahim, M. / 2006 / 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5 / Carcinogenesis 27:717~728
Hye-Na Ahn / 2014 / Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus / Biomolecules & Therapeutics 22(4):347~354
Bhat, T. A. / 2017 / Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer / Biochim. Biophys. Acta 1867:58~66
Chen, M. Y. / 2002 / Acute toxicity, mutagenicity, and estrogenicity of bisphenol-A and other bisphenols / Environ. Toxicol. 17:80~86
Coelingh Bennink, H. J. / 2004 / Are all estrogens the same? / Maturitas 47:269~275
Hye-Na Ahn / 2014 / Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus / Biomolecules & Therapeutics 22(4):347~354
Bhat, T. A. / 2017 / Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer / Biochim. Biophys. Acta 1867:58~66
Chen, M. Y. / 2002 / Acute toxicity, mutagenicity, and estrogenicity of bisphenol-A and other bisphenols / Environ. Toxicol. 17:80~86
Coelingh Bennink, H. J. / 2004 / Are all estrogens the same? / Maturitas 47:269~275
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