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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 557 - 563 (7page)
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초록· 키워드
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Skin aging is the most readily observable process involved in human aging. Ultraviolet B (UVB) radiation causes photo-oxidation via generation of reactive oxygen species (ROS), thereby damaging the nucleus and cytoplasm of skin cells and ultimately leading to cell death. Recent studies have shown that high levels of solar UVB irradiation induce the synthesis of matrix metalloproteinases (MMPs) in skin fibroblasts, causing photo-aging and tumor progression. The MMP family is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes such as arthritis and metastasis. We investigated the effect of diphlorethohydroxycarmalol (DPHC) against damage induced by UVB radiation in human skin keratinocytes. In UVB-irradiated cells, DPHC significantly reduced expression of MMP mRNA and protein, as well as activation of MMPs. Furthermore, DPHC reduced phosphorylation of ERK and JNK, which act upstream of c-Fos and c-Jun, respectively; consequently, DPHC inhibited the expression of c-Fos and c-Jun, which are key components of activator protein-1 (AP-1, up-regulator of MMPs). Additionally, DPHC abolished the DNA-binding activity of AP-1, and thereby prevented AP-1-mediated transcriptional activation. These data demonstrate that by inactivating ERK and JNK, DPHC inhibits induction of MMPs triggered by UVB radiation.
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참고문헌 (44)
참고문헌 신청
Benbow, U. / 1997 / The AP-1 site and MMP gene regulation: what is all the fuss about? / Matrix Biol 15:519~526
Berne, B. / 1984 / UV treatment of uraemic pruritus reduces the vitamin A content of the skin / Eur. J. Clin. Invest 14:203~206
Bogoyevitch, M. A. / 2010 / c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges / Biochim. Biophys. Acta 1804:463~475
Brenneisen, P. / 1997 / Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fibroblasts / Free Radic. Biol. Med 22:515~524
Brenneisen, P. / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973:31~43
Berne, B. / 1984 / UV treatment of uraemic pruritus reduces the vitamin A content of the skin / Eur. J. Clin. Invest 14:203~206
Bogoyevitch, M. A. / 2010 / c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges / Biochim. Biophys. Acta 1804:463~475
Brenneisen, P. / 1997 / Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fibroblasts / Free Radic. Biol. Med 22:515~524
Brenneisen, P. / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973:31~43
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