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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 4 - 11 (8page)
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초록· 키워드
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Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the ${\beta}2$-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
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참고문헌 (52)
참고문헌 신청
Alexander, N. S. / 2014 / Energetic analysis of the rhodopsin-Gprotein complex links the α5 helix to GDP release / Nat. Struct. Mol. Biol 21:56~63
Coleman, D. E. / 1994 / Structures of active conformations of Gi α 1and the mechanism of GTP hydrolysis / Science 265:1405~1412
DeVree, B. T. / 2016 / Allosteric coupling from G protein to the agonist-binding pocket in GPCRs / Nature 535:182~186
Downes, G. B. / 1999 / The G protein subunit gene families / Genomics 62:544~552
Dror, R. O. / 2015 / Structural basis for nucleotide exchange in heterotrimeric G proteins / Science 348:1361~1365
Coleman, D. E. / 1994 / Structures of active conformations of Gi α 1and the mechanism of GTP hydrolysis / Science 265:1405~1412
DeVree, B. T. / 2016 / Allosteric coupling from G protein to the agonist-binding pocket in GPCRs / Nature 535:182~186
Downes, G. B. / 1999 / The G protein subunit gene families / Genomics 62:544~552
Dror, R. O. / 2015 / Structural basis for nucleotide exchange in heterotrimeric G proteins / Science 348:1361~1365
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