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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 26 - 43 (18page)
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Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors with specific binding sites for extracellular molecules internalize via vesicles. G protein-coupled receptors (GPCRs) are the largest single family of plasma-membrane receptors with more than 1000 family members. But the molecular mechanisms involved in the regulation of GPCRs are believed to be highly conserved. For example, receptor phosphorylation in collaboration with ${\beta}$-arrestins plays major roles in desensitization and endocytosis of most GPCRs. Nevertheless, a number of subsequent studies showed that GPCR regulation, such as that by endocytosis, occurs through various pathways with a multitude of cellular components and processes. This review focused on i) functional interactions between homologous and heterologous pathways, ii) methodologies applied for determining receptor endocytosis, iii) experimental tools to determine specific endocytic routes, iv) roles of small guanosine triphosphate-binding proteins in GPCR endocytosis, and v) role of post-translational modification of the receptors in endocytosis.
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참고문헌 (228)
참고문헌 신청
Acconcia, F. / 2005 / Palmitoylation-dependent estrogen receptor α membrane localization: regulation by 17β-estradiol / Mol. Biol. Cell 16:231~237
Adachi, N. / 2016 / Spalmitoylation of a novel site in the β2-adrenergic receptor associated with a novel intracellular itinerary / J. Biol. Chem 291:20232~20246
Adams, M. N. / 2011 / The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2 / PLoS ONE 6:e28018
Adlanmerini, M. / 2014 / Mutation of the palmitoylation site of estrogen receptor αin vivo reveals tissue-specific roles for membrane versus nuclear actions / Proc. Natl. Acad. Sci. U.S.A 111:E283~E290
Alaluf, S. / 1995 / Palmitoylation of metabotropic glutamate receptor subtype 4 but not 1 α expressed in permanently transfected BHK cells / Biochem. Soc. Trans 23:87S
Adachi, N. / 2016 / Spalmitoylation of a novel site in the β2-adrenergic receptor associated with a novel intracellular itinerary / J. Biol. Chem 291:20232~20246
Adams, M. N. / 2011 / The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2 / PLoS ONE 6:e28018
Adlanmerini, M. / 2014 / Mutation of the palmitoylation site of estrogen receptor αin vivo reveals tissue-specific roles for membrane versus nuclear actions / Proc. Natl. Acad. Sci. U.S.A 111:E283~E290
Alaluf, S. / 1995 / Palmitoylation of metabotropic glutamate receptor subtype 4 but not 1 α expressed in permanently transfected BHK cells / Biochem. Soc. Trans 23:87S
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