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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 92 - 100 (9page)
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초록· 키워드
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Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$, prostaglandin (PG) $E_2$, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated $Akt/IKK/NF-{\kappa}B$ pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and $TNF-{\alpha}$ by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting $Akt/IKK/I{\kappa}B/NF-{\kappa}B$ pathway and promoting Nrf-2/HO-1 pathway.
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참고문헌 (40)
참고문헌 신청
Akiyama H / 2000 / Inflammation and Alzheimer’s disease / Neurobiol. Aging 21:383~421
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu. Rev. Immunol 12:141~179
Bai D / 2009 / Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt / Int. J. Cancer 125:2863~2870
Choi DK / 2011 / Inhibitors of microglial neurotoxicity : focus on natural products / Molecules 16:1021~1043
Cianciulli A / 2016 / PI3K/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-acivated microglia / Int. Immunopharmacol 36:282~290
Baeuerle PA / 1994 / Function and activation of NF-kappa B in the immune system / Annu. Rev. Immunol 12:141~179
Bai D / 2009 / Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt / Int. J. Cancer 125:2863~2870
Choi DK / 2011 / Inhibitors of microglial neurotoxicity : focus on natural products / Molecules 16:1021~1043
Cianciulli A / 2016 / PI3K/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-acivated microglia / Int. Immunopharmacol 36:282~290
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