지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 517 - 522 (6page)
이용수
초록· 키워드
오류제보하기
${\beta}$-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of ${\beta}$-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and G protein-independent signaling. Thus, determining the GPCR regions involved in the interactions with ${\beta}$-arrestins would be a preliminary step in understanding the molecular mechanisms involved in the selective direction of each function. In the current study, we determined the roles of the N-terminus, intracellular loops, and C-terminal tail of a representative GPCR in the interaction with ${\beta}$-arrestin2. For this, we employed dopamine $D_2$ and $D_3$ receptors ($D_2R$ and $D_3R$, respectively), since they display distinct agonist-induced interactions with ${\beta}$-arrestins. Our results showed that the second and third intracellular loops of $D_2R$ are involved in the agonist-induced translocation of ${\beta}$-arrestins toward plasma membranes. In contrast, the N- and C-termini of $D_2R$ exerted negative effects on the basal interaction with ${\beta}$-arrestins.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Functional Regulation of Dopamine D<sub>3</sub> Receptor through Interaction with PICK1
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Role of Helix 8 in Dopamine Receptor Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Molecular Signature That Determines the Acute Tolerance of G Protein-Coupled Receptors
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Improvement of acute kidney injury by mesenchymal stem cell treated with dopamine D1 receptor agonist
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
Endocrinology and Metabolism
2021 .01
-
Effect of an Antagonistic Peptide of CCR5 on the Expression of Autophagy-related Genes and β-Arrestin 2 in Lung Tissues of Asthmatic Mice
Allergy, Asthma & Immunology Research
2021 .01
-
Synthetic cannabinoids-induced reward behavior is associated with cannabinoid receptor 1 receptor and dopamine transporter function
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Human CD8+ T-Cell Populations That Express Natural Killer Receptors
Immune Network
2023 .02
-
Effects of ginseng on two main sex steroid hormone receptors : estrogen and androgen receptors
Journal of Ginseng Research
2017 .04
-
P2Y<sub>6</sub> 수용체 길항제의 파골세포 분화 촉진 효과 규명
약학회지
2015 .01
-
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Administration of Alpha<sub>s1</sub>-Casein Hydrolysate Increases Sleep and Modulates GABA<sub>A</sub> Receptor Subunit Expression
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Expression of Growth Factor Receptor Family Before and After Targeted Therapy in Human Epidermal Growth Factor Receptor-2 Positive Breast Cancer Tissues
대한임상종양학회 학술대회지
2015 .02
-
Dopamine-mediated reward-related behaviors : optogenetic analysis
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Dopamine D1-like receptor regulates GAD-67 expression following degeneration of dopaminergic neuron
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Dopamine D1 receptor agonist modulates the expression of glutamic acid decarboxylase 67 by heparanase-1 in 6-hydroxydopamineinduced neurodegeneration
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Activation of Dopamine D2 Receptor Alleviates Neuroinflammation in a Mouse Model of Allergic Rhinitis With Olfactory Dysfunction
Allergy, Asthma & Immunology Research
2021 .11
-
Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea
Cancer Research and Treatment
2021 .10
-
Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine
Journal of Biomedical and Translational Research
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0