지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 147 - 155 (9page)
이용수
초록· 키워드
오류제보하기
Background: Methamphetamine (METH) is the most widely used psychostimulant and has been known to exhibit reinforcing effects even after long abstinence. We showed the inhibitory effect of Korean Red Ginseng extract (RGE) on METH-induced addictive behaviors in animal models mimicking the human drug-use pattern.
Methods: We first investigated the effect of RGE on the acquisition of METH-induced dependence using self-administration and conditioned place preference (CPP) tests. Additionally, further experiments such as METH-induced motivational behavior and seeking behavior were conducted. To study the underlying mechanism, dopamine receptor, dopamine transporter, and N-methyl-D-aspartate receptor were assessed through Western blot analysis.
Results: Treatment with RGE significantly reduced METH-induced self-administration on a fixed-ratio 1 schedule of reinforcement. It could be also decreased a progressive ratio schedule, and inhibited METHprimed reinstatement. In CPP, RGE significantly prevented the development of METH-induced CPP. Moreover, RGE not only shortened the withdrawal period clearly, but also prevented the reinstatement of CPP. RGE treatment also reversed METH-induced overexpression of dopamine transporter, dopamine receptor D1, and NMDA receptor in the nucleus accumbens.
Conclusion: Our findings reflect that RGE has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system.
Methods: We first investigated the effect of RGE on the acquisition of METH-induced dependence using self-administration and conditioned place preference (CPP) tests. Additionally, further experiments such as METH-induced motivational behavior and seeking behavior were conducted. To study the underlying mechanism, dopamine receptor, dopamine transporter, and N-methyl-D-aspartate receptor were assessed through Western blot analysis.
Results: Treatment with RGE significantly reduced METH-induced self-administration on a fixed-ratio 1 schedule of reinforcement. It could be also decreased a progressive ratio schedule, and inhibited METHprimed reinstatement. In CPP, RGE significantly prevented the development of METH-induced CPP. Moreover, RGE not only shortened the withdrawal period clearly, but also prevented the reinstatement of CPP. RGE treatment also reversed METH-induced overexpression of dopamine transporter, dopamine receptor D1, and NMDA receptor in the nucleus accumbens.
Conclusion: Our findings reflect that RGE has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
Journal of Ginseng Research
2022 .05
-
Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
Journal of Ginseng Research
2015 .04
-
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
Journal of Ginseng Research
2022 .01
-
A comparative study on immune-stimulatory and antioxidant activities of various types of ginseng extracts in murine and rodent models
Journal of Ginseng Research
2018 .10
-
Red ginseng extract inhibits lipopolysaccharide-induced platelet-leukocyte aggregates in mice
Journal of Ginseng Research
2024 .07
-
Effect of Korean Red Ginseng extract on colorectal lung metastasis through inhibiting the epitheliale-mesenchymal transition via transforming growth factor-β1/Smad-signaling-mediated Snail/E-cadherin expression
Journal of Ginseng Research
2019 .01
-
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes
Journal of Ginseng Research
2021 .05
-
Protective role of saponin derived from Korean Red Ginseng in keratinocytes
한국실험동물학회 학술발표대회 논문집
2021 .07
-
A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
Journal of Ginseng Research
2019 .01
-
Functional Regulation of Dopamine D<sub>3</sub> Receptor through Interaction with PICK1
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro
Journal of Ginseng Research
2017 .04
-
Corrigendum to “Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models” [J Ginseng Res 46 (2022) 426-434]
Journal of Ginseng Research
2023 .03
-
대황 감초 복합추출물의 항산화 효과를 통한 역류성 식도염 개선 효과
대한본초학회지(본초분과학회지)
2015 .01
-
Korean Red Ginseng and Portulaca oleracea Extracts Attenuate Lipopolysaccharide-induced Inflammation via Downregulation of Nuclear Factor Kappa-B and the Mitogen-activated Protein Kinase Signaling Pathway in Macrophage Cell Line RAW 264.7
대한의생명과학회지
2021 .06
-
Limonene Inhibits Methamphetamine-Induced Sensitizations via the Regulation of Dopamine Receptor Supersensitivity
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation
Journal of Ginseng Research
2017 .10
-
Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts
Journal of Ginseng Research
2022 .05
-
A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng)
Journal of Ginseng Research
2018 .06
-
Ginsenoside Rg3-enriched Korean Red Ginseng extract attenuates Non-Alcoholic Fatty Liver Disease by way of suppressed VCAM-1 expression in liver sinusoidal endothelium
Journal of Ginseng Research
2023 .05
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-524-001132693