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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 374 - 379 (6page)
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In this study, we investigated the effects of pelargonidin, an anthocyanidin found in many fruits and vegetables, on endothelium-independent vascular contractility to determine the underlying mechanism of relaxation. Isometric contractions of denuded aortic muscles from male rats were recorded, and the data were combined with those obtained in western blot analysis. Pelargonidin significantly inhibited fluoride-, thromboxane A2-, and phorbol ester-induced vascular contractions, regardless of the presence or absence of endothelium, suggesting a direct effect of the compound on vascular smooth muscles via a different pathway. Pelargonidin significantly inhibited the fluoride-dependent increase in the level of myosin phosphatase target subunit 1 (MYPT1) phosphorylation at Thr-855 and the phorbol 12,13-dibutyrate-dependent increase in the level of extracellular signal-regulated kinase (ERK) 1/2 phosphorylation at Thr202/Tyr204, suggesting the inhibition of Rho-kinase and mitogen-activated protein kinase kinase (MEK) activities and subsequent phosphorylation of MYPT1 and ERK1/2. These results suggest that the relaxation effect of pelargonidin on agonist-dependent vascular contractions includes inhibition of Rho-kinase and MEK activities, independent of the endothelial function.
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참고문헌 (32)
참고문헌 신청
Ajay, M. / 2003 / Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta / Life Sci. 74:603~612
Akata, T. / 2007 / Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells / J. Anesth. 21:232~242
Amano, M. / 1996 / Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) / J. Biol. Chem. 271:20246~20249
Appel, L. J. / 2006 / Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association / Hypertension 47:296~308
Brietz, A. / 2016 / Analyzing ERK 1/2 signalling and targets / Mol. Biosyst. 12:2436~2446
Akata, T. / 2007 / Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells / J. Anesth. 21:232~242
Amano, M. / 1996 / Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) / J. Biol. Chem. 271:20246~20249
Appel, L. J. / 2006 / Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association / Hypertension 47:296~308
Brietz, A. / 2016 / Analyzing ERK 1/2 signalling and targets / Mol. Biosyst. 12:2436~2446
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