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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제61권 제3호
- 발행연도
- 2018.1
- 수록면
- 257 - 265 (9page)
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초록· 키워드
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The Panax ginseng Mayer is used in conventional medicine in Asia owing to its preventing effects on thrombosis, hypertension, atherosclerosis, vasorelaxation and myocardial infarction. Because platelets are crucial mediators of cardiovascular diseases, many studies have investigated its functions. The previous study showed the antiplatelet effects of crude ginseng fraction and two of its components, ginsenoside Rg3 (20S and 20R). In addition, ginsenoside Rg3-enriched fraction shows an inhibitory effect on collagen-activated rat platelets. However, the mechanism underlying this effect remains unclear. Thus, I investigated the inhibitory action of ginsenoside Rg3 (20S, G-Rg3) on the regulation of signaling molecules involved in ${\alpha}IIb/{\beta}_3$ activation. I found that G-Rg3, in a cyclic AMP dependent manner, inhibited thrombin-induced activation of human platelets and affinity of fibrinogen and fibronectin with ${\alpha}IIb/{\beta}_3$. Thus, in the present study, G-Rg3 showed an inhibitory effect on glycoprotein IIb/IIIa (${\alpha}IIb/{\beta}_3$) activation, suggesting its potential use for preventing platelet-mediated thrombotic disease.
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참고문헌 (23)
참고문헌 신청
Phillips DR / 2001 / Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling / Thromb Haemost 86:246~258
Smolenski A / 2012 / Novel roles of cAMP/cGMP-dependent signaling in platelets / J Thromb Haemost 10:167~176
Laurent V / 1999 / Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes / J Cell Biol 144:1245~1258
Sudo T / 2003 / Phosphorylation of the vasodilatorstimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets / Platelets 14:381~390
Matsuda H / 1985 / Pharmacological Study on Panax ginseng CA MEYER V.: Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (4). On Ginsenoside-Rg3, Rh1 and Rh2 / The Japanese Society of Pharmacognosy 39:123~125
Smolenski A / 2012 / Novel roles of cAMP/cGMP-dependent signaling in platelets / J Thromb Haemost 10:167~176
Laurent V / 1999 / Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes / J Cell Biol 144:1245~1258
Sudo T / 2003 / Phosphorylation of the vasodilatorstimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets / Platelets 14:381~390
Matsuda H / 1985 / Pharmacological Study on Panax ginseng CA MEYER V.: Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (4). On Ginsenoside-Rg3, Rh1 and Rh2 / The Japanese Society of Pharmacognosy 39:123~125
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