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- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제60권 제1호
- 발행연도
- 2017.1
- 수록면
- 29 - 33 (5page)
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The methanol extract of Rhododendron mucronulatum for. albiflorum (RMFA) stems inhibited aldose reductase (AR) activity. The RMFA fractions obtained by stepwise extraction with solvents of different polarity were tested for AR inhibition in vitro using the lens of a rat. Among them, the ethyl acetate (EtOAc) fraction inhibited AR more than the other fractions. Quercetin (1) from the EtOAc fraction showed a high AR inhibition with $IC_{50}$ of $2.11{\mu}M$. The stems of RMFA contained the highest amount (5.12 mg/g extract) of quercetin. Our results suggest that RMFA, which contained quercetin, could be a useful material for the development of supplementary functional foods.
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참고문헌 (23)
참고문헌 신청
안봉전 / 2005 / 진달래꽃(Rhododendron mucronulatum Turczaninow) 추출물의항산화, 항암 효과 및 tyrosinase 저해활성 / Applied Biological Chemistry 48(3):280~284
Enomoto S / 2004 / Inhibitory effect oftraditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L / Biol Pharm Bull 27:1140~1143
Guleria S / 2011 / Comparative studies of volatile oil composition of Rhododendron anthopogon by hydro distillation,s upercritical carbondioxide extraction and head spaceanalysis / Nat Prod Res 25:1271~1277
Gunduz A / 2007 / Mad honey poisoning-related asystole / Am Med J 24:592~593
Gunduz A / 2008 / Clinical review of grayano-toxin/mad honey poisoning past and present / Clin Toxicol 46:437~442
Enomoto S / 2004 / Inhibitory effect oftraditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L / Biol Pharm Bull 27:1140~1143
Guleria S / 2011 / Comparative studies of volatile oil composition of Rhododendron anthopogon by hydro distillation,s upercritical carbondioxide extraction and head spaceanalysis / Nat Prod Res 25:1271~1277
Gunduz A / 2007 / Mad honey poisoning-related asystole / Am Med J 24:592~593
Gunduz A / 2008 / Clinical review of grayano-toxin/mad honey poisoning past and present / Clin Toxicol 46:437~442
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