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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 65 - 71 (7page)
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초록· 키워드
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Cell-free nucleic acids (cf-NAs) originate in trophoblasts and are detected in the maternal plasma. Using innovative bioinformatic technologies such as next-generation sequencing, cf-NAs in the maternal plasma have been rapidly applied in prenatal genetic screening for fetal aneuploidy. Amniotic fluid is a complex and dynamic fluid that provides growth factors and protection to the fetus. In 2001, the presence of cf-NA in amniotic fluid was reported. Amniotic fluid is in direct contact with the fetus and is derived from fetal urine and maternal and fetal plasma. Therefore, these genetic materials have been suggested to reflect fetal health and provide real-time genetic information regarding fetal development. Recently, several studies evaluated the global gene expression changes of amniotic fluid cell-free RNA according to gestational age. In addition, by analyzing the transcriptome in the amniotic fluid of fetal aneuploidy, potential key pathways and novel biomarkers for fetal chromosomal aneuploidy were identified. Here, we review the current knowledge of cell-free RNA in amniotic fluid and suggest future research directions.
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참고문헌 (29)
참고문헌 신청
Lo YM / 1997 / Presence of fetal DNA in maternal plasma and serum / Lancet 350:485~487
Mersy E / 2013 / Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012 / Hum Reprod Update 19:318~329
Lo YM / 1998 / Quantitative analysis of fetal DNA in maternal plasma and serum:implications for noninvasive prenatal diagnosis / Am J Hum Genet 62:768~775
Bianchi DW / 2001 / Large amounts of cell-free fetal DNA are present in amniotic fluid / Clin Chem 47:1867~1869
Masuzaki H / 2004 / Detection of cell free placental DNA in maternal plasma : direct evidence from three cases of confined placental mosaicism / J Med Genet 41:289~292
Mersy E / 2013 / Noninvasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012 / Hum Reprod Update 19:318~329
Lo YM / 1998 / Quantitative analysis of fetal DNA in maternal plasma and serum:implications for noninvasive prenatal diagnosis / Am J Hum Genet 62:768~775
Bianchi DW / 2001 / Large amounts of cell-free fetal DNA are present in amniotic fluid / Clin Chem 47:1867~1869
Masuzaki H / 2004 / Detection of cell free placental DNA in maternal plasma : direct evidence from three cases of confined placental mosaicism / J Med Genet 41:289~292
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