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자료유형
학술저널
저자정보
Lee, Gi-Hyun (Department of Physiology, College of Oriental Medicine, Kyung Hee University) Kim, Han-Kyum (Department of Physiology, College of Oriental Medicine, Kyung Hee University) Lee, Hyo-Jung (Department of Physiology, College of Oriental Medicine, Kyung Hee University) Shin, Min-Kyu (Department of Physiology, College of Oriental Medicine, Kyung Hee University) Hong, Moo-Chang (Department of Physiology, College of Oriental Medicine, Kyung Hee University) Bae, Hyun-Su (Department of Physiology, College of Oriental Medicine, Kyung Hee University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제6권 제3호
발행연도
2010.1
수록면
255 - 259 (5page)

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Scutellaria barbata (S. barbata) is a perennial herb that is used to treat types of cancer, inflammation and urinary disease throughout Asia. Cisplatin is known as one of the most active cytotoxic anti-cancer drug. However, the nephrotoxicity which is the side-effect of cisplatin limits the use of it. In the present research, we examine whether S. barbata has protective effects on cisplatin induced acute renal failure in mice. S. barbata was administrated by oral once a day for three days (300 mg/kg body wt). After three days, all groups of mice received a single dose of cisplatin at 25 mg/kg (body wt) intra peritoneally. S. barbata pretreatment ameliorated renal dysfunction at 72 h after cisplatin injection. Compared to the control group, S. barbata pretreated group had significantly reduced the levels of pro-inflammatory cytokines and less tubular injury. These results confirm that S. barbata is a potent herbal medicine that reduces cisplatin nephrotoxicity and prevents the renal toxic effects of cisplatin.

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