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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 214 - 220 (7page)
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초록· 키워드
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Background Microvascular anastomosis patency is adversely affected by local and systemic factors. Impaired intimal recovery and endothelial mechanisms promoting thrombus formation at the anastomotic site are common etiological factors of reduced anastomosis patency. Epigallocatechin gallate (EGCG) is a catechin derivative belonging to the flavonoid subgroup and is present in green tea (Camellia sinensis). This study investigated the effects of EGCG on the structure of vessel tips used in microvascular anastomoses and evaluated its effects on thrombus formation at an anastomotic site. Methods Thirty-six adult male Wistar albino rats were used in the study. The right femoral artery was cut and reanastomosed. The rats were divided into two groups (18 per group) and were systemically administered either EGCG or saline. Each group were then subdivided into three groups, each with six rats. Axial histological sections were taken from segments 1 cm proximal and 1 cm distal to the microvascular anastomosis site on days 5, 10, and 14. Results Thrombus formation was significantly different between the EGCG and control groups on day 5 (P=0.015) but not on days 10 or 14. The mean luminal diameter was significantly greater in the EGCG group on days 5 (P=0.002), 10 (P=0.026), and 14 (P=0.002). Intimal thickening was significantly higher on days 5 (P=0.041) and 10 (P=0.02). Conclusions EGCG showed vasodilatory effects and led to reduced early thrombus formation after microvascular repair. Similar studies on venous anastomoses and random or axial pedunculated skin flaps would also contribute valuable findings relevant to this topic.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Tatlidede S / 2003 / Effects of vinblastine on healing in microvascular anastomosis / Microsurgery 23:354~358
Karsidag S / 2011 / Effects of vinblastine on microvascular anastomosis healing in diabetic rats / Acta Orthop Traumatol Turc 45:446~452
Eom JS / 2010 / Antithrombotic efficacy of an oral low molecular weight heparin conjugated with deoxycholic asset on microsurgical anastomosis in rats / Thromb Res 126:e220~e224
Brown JS / 2000 / Effect of short-term high dose of steroids on the healing of microvascular anastomoses in a rabbit model : pilot study / Br J Oral Maxillofac Surg 38:167~172
Park BY / 2014 / The effect of botulinum toxin B pretreatment to the blood flow in the microvascular anastomosis / Ann Plast Surg 72:214~219
Karsidag S / 2011 / Effects of vinblastine on microvascular anastomosis healing in diabetic rats / Acta Orthop Traumatol Turc 45:446~452
Eom JS / 2010 / Antithrombotic efficacy of an oral low molecular weight heparin conjugated with deoxycholic asset on microsurgical anastomosis in rats / Thromb Res 126:e220~e224
Brown JS / 2000 / Effect of short-term high dose of steroids on the healing of microvascular anastomoses in a rabbit model : pilot study / Br J Oral Maxillofac Surg 38:167~172
Park BY / 2014 / The effect of botulinum toxin B pretreatment to the blood flow in the microvascular anastomosis / Ann Plast Surg 72:214~219
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