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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 179 - 189 (11page)
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초록· 키워드
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Green tea polyphenol (?)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant with protective effects against neurotoxicity. However, it is currently unclear whether EGCG protects neuronal cells against radiation-induced damage. Therefore, the objective of this study was to investigate the effects of EGCG on ultraviolet (UV)-induced oxidative stress and apoptosis in PC12 cells. The effects of UV irradiation included apoptotic cell death, which was associated with DNA fragmentation, reactive oxygen species (ROS) production, enhanced caspase-3 and caspase-9 activity, and poly (ADP-ribose) polymerase cleavage. UV irradiation also increased the Bax/Bcl-2 ratio and mitochondrial pathway-associated cytochrome c expression. However, pretreatment with EGCG before UV exposure markedly decreased UV-induced DNA fragmentation and ROS production. Furthermore, the UV irradiationinduced increase in Bax/Bcl-2 ratio, cytochrome c upregulation, and caspase-3 and caspase-9 activation were each ameliorated by EGCG pretreatment. Additionally, EGCG suppressed UV-induced phosphorylation of p38 and rescued UV-downregulated phosphorylation of ERK. Taken together, these results suggest that EGCG prevents UV irradiationinduced apoptosis in PC12 cells by scavenging ROS and inhibiting the mitochondrial pathways known to play a crucial role in apoptosis. In addition, EGCG inhibits UV-induced apoptosis via JNK inactivation and ERK activation in PC12 cells. Thus, EGCG represents a potential neuroprotective agent that could be applied to prevent neuronal cell death induced by UV irradiation.
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참고문헌 (46)
참고문헌 신청
Yasuhiro Matsumura / 2004 / Toxic effects of ultraviolet radiation on the skin / Toxicology and Applied Pharmacology 195(3):298~308
Vladislava O. Melnikova / 2005 / Cellular and molecular events leading to the development of skin cancer / Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 571(1-2):91~106
Runa Masuma / 2013 / Effects of UV wavelength on cell damages caused by UV irradiation in PC12 cells / Journal of Photochemistry and Photobiology B: Biology 125:202~208
Weidong Jiang / 1999 / p53 protects against skin cancer induction by UV-B radiation / Oncogene 18(29):4247~4253
Kunala Subrahmanyam / 1991 / Ultraviolet light-induced unscheduled DNA-synthesis in isolated neurons of rat brain of different ages / Mechanisms of Ageing and Development 57(3):283~291
Vladislava O. Melnikova / 2005 / Cellular and molecular events leading to the development of skin cancer / Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 571(1-2):91~106
Runa Masuma / 2013 / Effects of UV wavelength on cell damages caused by UV irradiation in PC12 cells / Journal of Photochemistry and Photobiology B: Biology 125:202~208
Weidong Jiang / 1999 / p53 protects against skin cancer induction by UV-B radiation / Oncogene 18(29):4247~4253
Kunala Subrahmanyam / 1991 / Ultraviolet light-induced unscheduled DNA-synthesis in isolated neurons of rat brain of different ages / Mechanisms of Ageing and Development 57(3):283~291
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