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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 1,153 - 1,167 (15page)
- DOI
- 10.13000/JFMSE.2020.10.32.5.1153
이용수
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초록· 키워드
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Interferon regulatory factor 3 (IRF3) plays an important role in inducing the transcription of type I interferon (IFN) and IFN-stimulated genes (ISGs) following infection. We analysed the open reading frame (ORF) cDNA, genomic structure, and temporal variations in the mRNA transcription of IRF3 after challenge with Streptococcus iniae (S. iniae), Edwardsiella piscicida (E. piscicida), and red sea bream iridovirus (RSIV) in red sea bream Pagrus major (Pm). P. major IRF3 (PmIRF3) consisted an ORF of 1398 bp, encoding a polypeptide of 465 amino acids with an isoelectric point of 4.7 and theoretical molecular weight of 51.6 kDa. The strongest expression of PmIRF3 mRNA in healthy red sea bream was observed in the whole blood. The expression pattern of PmIRF3 mRNA after infection with pathogens was analysed in the gills, liver, kidney, and spleen. The quantitative real-time PCR (RT-qPCR) results showed that PmIRF3 mRNA expression was significantly elevated in the liver 1 h post-E. piscicida injection (P < 0.001). PmIRF3 expression increased significantly in most tissues 1 h post-S. iniae injection. PmIRF3 expression was also upregulated in the liver 12 h post-RSIV injection. These results indicate that IRF3 may play an important role in the immune response of P. major following pathogenic infections.
목차
Abstract
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과 및 고찰
References
참고문헌 (62)
참고문헌 신청
Wei-Chun Au / 1998 / Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes / Journal of Biological Chemistry 273(44):29210~29217
W. C. Au / 1995 / Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. / Proceedings of the National Academy of Sciences 92(25):11657~11661
Betsy Barnes / 2002 / Review: On the Role of IRF in Host Defense / Journal of Interferon & Cytokine Research 22(1):59~71
Angela Battistini / 2009 / Interferon Regulatory Factors in Hematopoietic Cell Differentiation and Immune Regulation / Journal of Interferon & Cytokine Research 29(12):765~780
Weijun Chen / 2010 / Structural insights into interferon regulatory factor activation / Cellular Signalling 22(6):883~887
W. C. Au / 1995 / Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. / Proceedings of the National Academy of Sciences 92(25):11657~11661
Betsy Barnes / 2002 / Review: On the Role of IRF in Host Defense / Journal of Interferon & Cytokine Research 22(1):59~71
Angela Battistini / 2009 / Interferon Regulatory Factors in Hematopoietic Cell Differentiation and Immune Regulation / Journal of Interferon & Cytokine Research 29(12):765~780
Weijun Chen / 2010 / Structural insights into interferon regulatory factor activation / Cellular Signalling 22(6):883~887
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