지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 368 - 375 (8page)
이용수
초록· 키워드
오류제보하기
Metabolic syndrome (MetS) is a disease that is accompanied by various metabolic related problems and refers to a disease in which various adult diseases occur along with obesity. These metabolic syndromes appear according to the individual"s genetic background. APOA5-ZPR1-BUD13, a gene cluster belonging to chromosome 11q23.3, is well known for its risk of plasma triglycerides and coronary artery disease. Recently, the GWAS results for metabolic syndrome were published in Koreans. The results included the APOA5-ZPR1-BUD13, and the SNPs that first appeared in Koreans in the ZPR1 and BUD13 were also discovered. In this study, the reproducibility was investigated for the newly discovered ZPR1 (rs964184) and BUD13 (rs2075295, rs1558861) using The Health Examinees (HEXA) cohort and showed significance. In addition, BUD13 (rs117548857, rs10488698, rs149527022, rs10790162), ZPR1 (rs2075290, rs145796806, rs201247587), APOA5 (rs12791103, rs1263173, rs7396835, rs17520254) were additionally discovered and significant results were obtained. For the SNPs that showed significant results, the effect on protein expression and the effect of expression quantitative trait loci (eQTL) were also confirmed. This study is expected to contribute to the prevention and treatment of diseases with differences in onset based on individual genetic patterns as well as presenting the effect of genetic mutations in the APOA5-ZPR1-BUD13 on metabolic syndrome and blood lipid levels.
목차
서론
대상 및 방법
결과
고찰
REFERENCES
참고문헌 (10)
참고문헌 신청
Aguilar M / 2015 / Prevalence of the metabolic syndrome in the United States, 2003-2012 / JAMA 313:1973~1974
Brooks MA / 2009 / Structure of the yeast Pml1 splicing factor and its integration into the RES complex / Nucleic Acids Res 37:129~143
Corton JC / 2000 / Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators / Annu Rev Pharmacol Toxicol 40:491~518
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) / JAMA 285:2486~2497
Eckel RH / 2005 / The metabolic syndrome / Lancet 365:1415~1428
Brooks MA / 2009 / Structure of the yeast Pml1 splicing factor and its integration into the RES complex / Nucleic Acids Res 37:129~143
Corton JC / 2000 / Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators / Annu Rev Pharmacol Toxicol 40:491~518
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) / JAMA 285:2486~2497
Eckel RH / 2005 / The metabolic syndrome / Lancet 365:1415~1428
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