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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.1
- 발행연도
- 2021.3
- 수록면
- 75 - 81 (7page)
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초록· 키워드
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This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10- treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
Bekatorou A / 2006 / Production of food grade yeasts / Food Technol Biotechnol 44:407~415
Dodurka T / 1995 / Alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamate dehydrogenase(GLDH), alkaline phosphatase(AP)and gamma-glutamyltransferase(GGP)in intestinal diseases of dogs / Berl Munch Tierarztl Wochenschr 108:244~248
Giknis MLA / 2006 / Clinical laboratory parameters for Crl:CD (SD) rats / Charles River Laboratories :1~14
홍종욱 / 2004 / 효모가수분해물 SCP-20의 첨가가 웅성 마우스의 생식 기능에 미치는 영향 / 한국식품영양과학회지 33(2):451~454
Jung EY / 2012 / Effects of yeast hydrolysate on hepatic lipid metabolism in highfat-diet-induced obese mice: yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis / Ann Nutr Metab 61:89~94
Dodurka T / 1995 / Alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamate dehydrogenase(GLDH), alkaline phosphatase(AP)and gamma-glutamyltransferase(GGP)in intestinal diseases of dogs / Berl Munch Tierarztl Wochenschr 108:244~248
Giknis MLA / 2006 / Clinical laboratory parameters for Crl:CD (SD) rats / Charles River Laboratories :1~14
홍종욱 / 2004 / 효모가수분해물 SCP-20의 첨가가 웅성 마우스의 생식 기능에 미치는 영향 / 한국식품영양과학회지 33(2):451~454
Jung EY / 2012 / Effects of yeast hydrolysate on hepatic lipid metabolism in highfat-diet-induced obese mice: yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis / Ann Nutr Metab 61:89~94
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