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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 498 - 498 (1page)
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이 논문의 연구 히스토리 (7)
2020
Theasaponin E1 Reduce Amyloid beta (Aß) Accumulation by Suppressing Amyloidogenic APP Processing and Enhancing ADAM10 and Neprilysin Activation and Expression in APP-N2a Cells
Muhammad Im
,
an KHAN
,
Jin Hyuk SHIN
외 2명
한국생물공학회 학술대회
2020.06
학술대회자료
Green Tea Seed Isolated Saponins Attenuate Tau Hyperphosphorylation in SHY-5Y Cells by Downregulation of the Associated Kinases and Upregulation of Phosphatases in the Tau Phosphorylation Signaling Pathway
Muhammad Im
,
an KHAN
,
Muhammad Zubai
외 3명
한국생물공학회 학술대회
2020.06
학술대회자료
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Alzheimer’s disease (AD) is the most frequent type of dementia affecting memory, thinking and behaviour. The major hallmark of the disease is pathological neurodegeneration due to abnormal aggregation of Amyloid beta (Aβ) peptides generated by β- and γ-secretases via amyloidogenic pathway. To evaluate the effects of theasaponin E1 on the inhibition of Aβ producing β- and γ-secretases (BACE1, PS1& NCT) and acetyl-cholinesterase and activation of the non-amyloidogenic APP processing α-secretase (ADAM10). Also, Theasaponin E1 effects on Aβ degrading and clearing proteins neprilysin and insulin degrading enzyme (IDE). The effect of Theasaponin E1 on these crucial enzymes was investigated by RT-PCR, ELISA, western blotting and fluorometric assays using mouse neuroblastoma cells (SweAPP N2a). Theasaponin E1 was extracted and purified from green tea seed extract via HPLC, and N2a cells were ... 전체 초록 보기
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Theasaponin E1 Decrease Aß Peptides Level in APP-N2a Cells by Activating and Enhancing Activities of the Aß Degrading Enzymes α- secretase and Neprilysin
한국생물공학회 학술대회
2019 .10
-
γ-Secretase in Alzheimer’s disease
Experimental and Molecular Medicine
2022 .04
-
Theasaponin E1 Attenuates Aβ Amyloid, Hyperphosphorylated Tau in SweAPP N2a and SHY-5Y Cells and Ameliorate Neruinflamation by Regulating the Related Signaling Molecules and Enzymes
한국생물공학회 학술대회
2022 .09
-
Extraction and Isolation of Theasaponin E1 from Green Tea Seeds and Pharmacological Investigation of Antiangiogenic, Anticancer and Anti-Hyperlipidemic Activities
한국생물공학회 학술대회
2015 .10
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Theasaponin E1 Reduce Amyloid beta (Aß) Accumulation by Suppressing Amyloidogenic APP Processing and Enhancing ADAM10 and Neprilysin Activation and Expression in APP-N2a Cells
한국생물공학회 학술대회
2020 .06
-
Therapeutic Suppression and Inhibition of Neurodegenerative and Alzheimer Promoting Proteins and Genes with Green Tea Seed Isolated Theasaponin E1
한국생물공학회 학술대회
2020 .10
-
Characterization of a New Anti-dementia β-secretase Inhibitory Peptide from Arctoscopus japonicus
Journal of Chitin and Chitosan
2018 .01
-
β-secretase Inhibitory Effects of Metanolic Extracts from Euphorbiaceae and Leguminosae against Alzheimer"s Disease
한국생물공학회 학술대회
2015 .10
-
Amelioration of Tauopathy via Suppression of Tau Hyperphosphorylation by Reducing the Expression Level of Various Involved Genes and Kinesis with Theasaponin E1, A Therapeutic Target for Alzheimer’s Treatment
한국생물공학회 학술대회
2021 .10
-
Amelioration of Taupathy via Suppression of Tau Hyperphosphorylation by Reducing the Expression Level of Various Involved Genes and Kinesis with Theasaponin E1, a Therapeutic Target for Alzheimer’s Treatment
한국생물공학회 학술대회
2021 .04
-
Stevia Isolated Compounds and Theasaponin E1 Synergistic Effects on Adipogenesis and Lipogenesis Inhibition by Suppression of the Obesity Promoting Signaling Pathways
한국생물공학회 학술대회
2022 .09
-
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
Experimental and Molecular Medicine
2020 .08
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Amyloid Precursor Protein Cleavage Nanolithography with β-secretase by Atomic Force Microscope
한국생물공학회 학술대회
2015 .10
-
Green Tea seed Isolated Saponins Exert Strong Antibiotics Effects and effectively inhibit Zoonosis Causing Salmonella Serovars In vitro and In vivo
한국생물공학회 학술대회
2019 .10
-
Neuroprotective Effects of Green Tea Seed Isolated Saponin by Inhibition of Aβ peptides Production due to Anti-acetylcholinesterase Activity and Downregulation of BACE1 and Presenilin-1 &2
한국생물공학회 학술대회
2019 .10
-
Anti-hyperlipidemic and Fat Pad Lowering Effects of Standardized Formulation of Rebaudioside A, Sativoside and Theasaponin E1 in Mice Fed with High-fat and High-carbohydrate Diet
한국생물공학회 학술대회
2020 .10
-
Therapeutic Potential of Stem Cell-Derived Exosomes: Alleviating Neurodegeneration and Alzheimer"s Pathogenesis through Neuroinflammation Modulation and Molecular Pathway Regulation
한국생물공학회 학술대회
2023 .10
-
Effects of Radiofrequency Electromagnetic Fields and Ionizing Radiation on Amyloid Precursor Protein Processing and Cell Death
Journal of Electromagnetic Engineering And Science
2020 .10
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Amelioration of Angiogenesis, Adipogenesis and Lipogenesis to Attenuate Obesity by Targeting the Associated Promoting Signaling Molecules and Transcriptional Factors with Combination of Theasaponin E1, Stevioside and Rebaudioside A in Obesity Model Cells and Animals
한국생물공학회 학술대회
2021 .04
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Intracellular trafficking of TREM2 is regulated by presenilin 1
Experimental and Molecular Medicine
2017 .01
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