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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 9 - 9 (1page)
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Background : The roots of Angelica gigas Nakai (AGN), used to treat gynecological diseases such as anemia and menstrual pain, contain decursin (D), decursinol angelate (DA), and decursinol (DOH), a major metabolite. However, since the two index components (D and DA) have low solubility in water, they are extracted using organic solvents such as methanol and ethanol. However, since water is used in ordinary bath medicine, new material of AGN, which increases the water solubility of D and DA, is required. In the study, colloidal AGN was prepared for the increased water solubility through a hot-melt extrusion (HME) process by mixing AGN with an additive, and the water solubility of D and DA was measured by HPLC.
Methods and Results : Dried AGN cut to less than 5 ㎜ was mixed with additives (excipients) to solubilize the hydrophobic active component, and was fabricated through the HME process under heat and pressure. The AGN contents of HME-AGN 1, HME-AGN 2, HME-AGN 3 was 91, 87 and 81, respectively. Fo ... 전체 초록 보기
Methods and Results : Dried AGN cut to less than 5 ㎜ was mixed with additives (excipients) to solubilize the hydrophobic active component, and was fabricated through the HME process under heat and pressure. The AGN contents of HME-AGN 1, HME-AGN 2, HME-AGN 3 was 91, 87 and 81, respectively. Fo ... 전체 초록 보기
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