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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국수산과학회 양식분과 한국수산과학회 양식분과 학술대회 2021 Conference on the Future Technology of Fisheries Science [3개 분과 공동개최]
- 발행연도
- 2021.4
- 수록면
- 319 - 319 (1page)
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C-C Chemokine receptor 4 (CCR4) is a transmembrane G protein-coupled heptahelical receptor, specifically, bind and respond to cytokines of the C-C Chemokine family. The chemokine and chemokine receptor complex regulates important immune functions such as leukocyte trafficking, inflammation, immune cell differentiation. The sight of this study was the identification and characterization of Amphiprion clarkii CC Chemokine receptor 4-like (AcCCR4-like) gene. AcCCR4- like protein consists of 368 amino acids, the molecular weight is 42.17 KD with an isoelectric point of 8.56. AcCCR4-like structurally consists of an extracellular N-terminal, seven Transmembrane domains (TM domain), three extracellular loops, and three intercellular loops. A characteristic DRY motif is present in the second intracellular loop. Quantitative real-time PCR of tissue distribution unveiled that AcCCR4-like were ubiquitously expressed in all examined tissues, the highest expression was in gills followed by the spleen and the head kidney. The modulated mRNA expression pattern ... 전체 초록 보기
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