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논문 기본 정보

자료유형
학술저널
저자정보
Ji Yeun Kim (University of Ulsan College of Medicine) Seongman Bae (University of Ulsan College of Medicine) Soonju Park (Institut Pasteur Korea) Ji-Soo Kwon (University of Ulsan College of Medicine) So Yun Lim (University of Ulsan College of Medicine) Ji Young Park (University of Ulsan College of Medicine) Hye Hee Cha (University of Ulsan College of Medicine) Mi Hyun Seo (University of Ulsan College of Medicine) Hyun Jung Lee (University of Ulsan College of Medicine) Nakyung Lee (Institut Pasteur Korea) Jinyeong Heo (Institut Pasteur Korea) David Shum (Institut Pasteur Korea) Youngmee Jee (Institut Pasteur Korea) Sung-Han Kim (University of Ulsan College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.21 No.4
발행연도
2021.8
수록면
71 - 79 (9page)

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초록· 키워드

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There are limited data directly comparing humoral and T cell responses to the ChAdOx1 nCoV-19 and BNT162b2 vaccines. We compared Ab and T cell responses after first doses of ChAdOx1 nCoV-19 vs. BNT162b2 vaccines. We enrolled healthcare workers who received ChAdOx1 nCoV-19 or BNT162b2 vaccine in Seoul, Korea. Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein-specific IgG Abs (S1-IgG), neutralizing Abs (NT Abs), and SARS-CoV-2-specific T cell response were evaluated before vaccination and at 1-wk intervals for 3 wks after vaccination. A total of 76 persons, comprising 40 injected with the ChAdOx1 vaccine and 36 injected with the BNT162b2 vaccine, participated in this study. At 3 wks after vaccination, the mean levels (±SD) of S1-IgG and NT Abs in the BNT162b2 participants were significantly higher than in the ChAdOx1 participants (S1-IgG, 14.03±7.20 vs. 6.28±8.87, p<0.0001; NT Ab, 183.1±155.6 vs. 116.6±116.2, p=0.035), respectively. However, the mean values of the T cell responses in the 2 groups were comparable after 2 wks. The humoral immune response after the 1st dose of BNT162b2 developed faster and was stronger than after the 1st dose of ChAdOx1. However, the T cell responses to BNT162b2 and ChAdOx1 were similar.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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