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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 197 - 197 (1page)
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Repaglinide (RPG), a rapid‐acting meglitinide analog, is an oral hypoglycemic agent for patients with type 2 diabetes mellitus. Quercetin (QCT) is a well‐known antioxidant and antidiabetic flavonoid that has been used as an important ingredient in many functional foods and complementary medicines. This study aimed to comprehensively investigate the effects of QCT on the metabolism of RPG and its underlying mechanisms. Hepatic microsomal studies indicated that QCT weakly inhibits CYP-mediated metabolism, with IC50 value of 16.7 (13.0–18.6) μM and 3.0 (1.53–5.44) μM in rat liver microsome (RLM) and human liver microsome (HLM), respectively. The type of inhibition exhibited by QCT on RPG metabolism was determined to be a mixed inhibition with a Ki of 72.0 μM and 24. ... 전체 초록 보기
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