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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 210 - 210 (1page)
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As circulating autoantibodies and immune complex deposition is a pathological hallmark of systemic lupus erythematosus (SLE), B cell differentiation into plasma cells (PCs) and some T cell subsets functioning as B-cell helpers can be therapeutic target of SLE. Th17 and Treg cell imbalance is involved in the occurrence and development of SLE. Th17 cells and IL-17 cytokine promote autoantibodies from plasma B cell and kidney nephritis. Th17 cells are abundant in the gut because they are education and development in gut. Developmental Th17 cells from gut are migration to systemic organ in inflammatory condition. Fingolimod (FTY720) is mediated by the modulation of sphingosine-1 phosphate (S1P) receptor. Fingolimod phosphate binds to S1P1 receptors on lymphocytes, causing internalizatio ... 전체 초록 보기
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