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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 213 - 213 (1page)
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Auditory hair cells of the mammalian cochlea have a staircase arrangement of microvilli known as the stereocilia that are filled with actin filament on the apical surface. During inner ear development, kinocilium, the primary cilium of hair cell, moves from the center to the lateral pole, and the stereociliary bundles are arranged V-shaped with a vertex pointing to the kinocilium. This machinery is referred to as cell-intrinsic polarity. To form these unique structures, numerous proteins, such as GPSM2, DAPLE, and aPKCz, are confined to the restricted domains of the apical surface of hair cells. Mice inactivating these proteins or containing mutations in these proteins, such as Gai or GPSM2, have been shown to have fragmented and disorganized stereociliary bundles. However, the mechanisms of how hair cells form V-shaped stereociliary bundles in developing cochlea and the effect of disorganized hair bundles on hearing function remain largely unknown. SHANK2 is a multidomain-scaffolding protein implicated in the structu ... 전체 초록 보기
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