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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 529 - 537 (9page)
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초록· 키워드
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Most animals face frequent periods of starvation throughout their entire life and thus need to appropriately adjust their behavior and metabolism during starvation for their survival. Such adaptive responses are regulated by a complex set of systemic signals, including hormones and neuropeptides. While much progress has been made in identifying pathways that regulate nutrient-excessive states, it is still incompletely understood how animals systemically signal their nutrient-deficient states. Here, we showed that the FMRFamide neuropeptide FLP-20 modulates a systemic starvation response in Caenorhabditis elegans. We found that mutation of flp-20 rescued the starvation hypersensitivity of the G protein β-subunit gpb-2 mutants by suppressing excessive autophagy. FLP-20 acted in AIB neurons, where the metabotropic glutamate receptor MGL-2 also functions to modulate a systemic starvation response. Furthermore, FLP-20 modulated starvation-induced fat degradation in a manner dependent on the receptor-type guanylate cyclase GCY-28. Collectively, our results reveal a circuit that senses and signals nutrient-deficient states to modulate a systemic starvation response in multicellular organisms.
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등록된 정보가 없습니다.
참고문헌 (5)
참고문헌 신청
조동형 / 2020 / Mitophagy and Innate Immunity in Infection / Molecules and Cells 43(1):10~22
김진영 / 2018 / The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes / Molecules and Cells 41(1):11~17
권유진 / 2017 / Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot / Molecules and Cells 40(9):607~612
박지수 / 2019 / Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans / Molecules and Cells 42(1):28~35
신동욱 / 2020 / Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders / Molecules and Cells 43(8):686~693
김진영 / 2018 / The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes / Molecules and Cells 41(1):11~17
권유진 / 2017 / Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot / Molecules and Cells 40(9):607~612
박지수 / 2019 / Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans / Molecules and Cells 42(1):28~35
신동욱 / 2020 / Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders / Molecules and Cells 43(8):686~693
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