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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 134 - 142 (9page)
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Colon cancer is one of the most common malignant tumors, but there are still a few validated biomarkers of coloncancer. Exosome-mediated microRNAs (miRNAs) have been recognized as potential biomarkers in cancers, andmiRNAs can regulate a variety of genes. Recently, Fusobacterium nucleatum was discovered in the tissues of humancolon cancer patients. Its role in colon cancer was highlighted. F. nucleatum may contribute to the progression ofcolon cancer through the mechanism of exosome-mediated miRNAs transfer. However, the exosomal miRNAsregulation mechanism by F. nucleatum in colon cancer is not well known. Thus, we performed next-generationsequencing to investigate the overall pattern of exosomal miRNAs expression in the colon cancer cell culturesupernatant. We have confirmed the alterations of various exosomal miRNAs. In addition, to investigate the functionof exosomal miRNAs, a Kyoto Encyclopedia of Genes and Genomes analysis was performed on the target genesof changed miRNAs. Potential target genes were associated with a variety of signaling pathways, and one of thesepathways was related to colorectal cancer. These findings suggested that F. nucleatum can alter exosomal miRNAsreleased from colorectal cancer cells. Furthermore, exosomal miRNAs altered by F. nucleatum could be potentialbiomarkers for the diagnosis and therapy of colon cancer.
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참고문헌 (34)
참고문헌 신청
Junting Ma / 2018 / PIAS3-mediated feedback loops promote chronic colitis-associated malignant transformation / Theranostics 8(11):3022~3037
Joseph P. Zackular / 2016 / Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis / mSphere 1(1)::e00001-15
Chun-Hui Sun / 2019 / The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management / Chronic Diseases and Translational Medicine 5(3):178~187
Zhenhua Yang / 2019 / Fusobacterium nucleatum-positive colorectal cancer / Oncol Lett 18:975~982
xuebing yan / 2017 / Clinical significance of Fusobacterium nucleatum , epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients / OncoTargets and Therapy 10:5031~5046
Joseph P. Zackular / 2016 / Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis / mSphere 1(1)::e00001-15
Chun-Hui Sun / 2019 / The role of Fusobacterium nucleatum in colorectal cancer: from carcinogenesis to clinical management / Chronic Diseases and Translational Medicine 5(3):178~187
Zhenhua Yang / 2019 / Fusobacterium nucleatum-positive colorectal cancer / Oncol Lett 18:975~982
xuebing yan / 2017 / Clinical significance of Fusobacterium nucleatum , epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients / OncoTargets and Therapy 10:5031~5046
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