지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 187 - 192 (6page)
- DOI
- 10.21851/obr.45.04.202112.187
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초록· 키워드
오류제보하기
Fusobacterium nucleatum is an important endodontic pathogen, and prostaglandin E2 (PGE2) has important roles in the development and progression of inflammatory responses. In this study, we investigated the effects of F. nucleatum on PGE2 production in human dental pulp cells (HDPCs). Cells were stimulated with F. nucleatum and PGE2 protein and cyclooxygenase (COX)-1/2 mRNA levels determined by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction, respectively. The activation of mitogen-activated protein (MAP) kinases was examined by Western blotting. F. nucleatum strains increased PGE2 production by HDPCs in a dose-dependent manner. Moreover, strain 10953 made a stronger response than strain 49256. F. nucleatum dosedependently increased COX-2 mRNA levels without affecting COX-1 expression. Furthermore, celecoxib, a selective COX-2 inhibitor, blocked PGE2 production by F. nucleatum. Finally, F. nucleatum activated all three MAP kinases. The pharmacological inhibition of each MAP kinase significantly attenuated F. nucleatum-induced PGE2 production. These results suggested F. nucleatum induced COX- 2-mediated PGE2 production by HDPCs by activating MAP kinases, thereby promoting endodontic inflammation.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
I. F. Persoon / 2017 / Definitions and Epidemiology of Endodontic Infections / Current Oral Health Reports 4(4):278~285
Ashraf F. Fouad / 2017 / Endodontic Microbiology and Pathobiology / Dental Clinics of North America 61(1):1~15
LLakshmi Narayanan / 2010 / Endodontic microbiology / Journal of Conservative Dentistry 13(4):233~239
Brenda P. F. A. Gomes / 2021 / Identification of Fusobacterium nucleatum in primary and secondary endodontic infections and its association with clinical features by using two different methods / Clinical Oral Investigations 12
Yiping W Han / 2015 / Fusobacterium nucleatum: a commensal-turned pathogen / Current Opinion in Microbiology 23:141~147
Ashraf F. Fouad / 2017 / Endodontic Microbiology and Pathobiology / Dental Clinics of North America 61(1):1~15
LLakshmi Narayanan / 2010 / Endodontic microbiology / Journal of Conservative Dentistry 13(4):233~239
Brenda P. F. A. Gomes / 2021 / Identification of Fusobacterium nucleatum in primary and secondary endodontic infections and its association with clinical features by using two different methods / Clinical Oral Investigations 12
Yiping W Han / 2015 / Fusobacterium nucleatum: a commensal-turned pathogen / Current Opinion in Microbiology 23:141~147
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