지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 39 - 53 (15page)
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초록· 키워드
오류제보하기
Colorectal cancer (CRC) is recognized as the third most common malignancy worldwide. Previous studies indicated several genetic and environmental factors that potentiate CRC. However, the role of microbiota in the etiology of CRC is becoming a major concern nowadays. Fusobacterium nucleatum (F. nucleatum), an anaerobic bacterium, mostly resides in the oral cavity and is a causative agent of various oral inflammatory diseases. It is evident from the recent studies that F. nucleatum is present in abundance in the CRC tissues as compared to the adjacent normal tissues. F. nucleatum has certain virulence factors like FadA and Fap2 which help in its adhesion to the mucosal cells and promotes carcinogenesis. Besides that, these virulence factors induce cytokine production and recruitment of inflammatory cells, hence it creates an environment favorable for neoplastic growth. Furthermore, F. nucleatum can suppress the host immune system by interfering with normal functions of macrophages, dendritic cells, T cells, tumor-associated neutrophils and natural killer cells. It was also revealed that CRC patients with high numbers of F. nucleatum showed drug resistance and cancer recurrence. From the previous investigations, it was concluded that F. nucleatum has a diagnostic as well as prognostic value for CRC patients. In the present study, we have outlined the current data on the detection methods, pathogenic mechanisms, immunosuppression effects and clinical management of F. nucleatum-associated CRC.
목차
INTRODUCTION
DETECTION METHODS OF F. NUCLEATUM IN CRC
POTENTIAL ROLE OF F. NUCLEATUM IN CRC
F. NUCLEATUM PROMOTES EPIGENETIC CHANGES IN CRC
F. NUCLEATUM AND HOST IMMUNITY
ROLE OF F. NUCLEATUM IN DRUG RESISTANCE
SCREENING AND PREVENTION STRATEGIES OF F. NUCLEATUM-ASSOCIATED CRC
CLINICAL MANAGEMENT OF F. NUCLEATUM-ASSOCIATED CRC
CONCLUSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2021-475-001844461