지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: The purpose of the present study was to evaluate the preventive effects of ethanol extract of Polygalae radix (EEPR) against oxidative stress (hydrogen peroxide, $H_2O_2$)-induced DNA damage and apoptosis in Chang liver cells. Methods: Chang liver cells were pretreated with various concentrations of EEPR and then challenged with 0.5 mM $H_2O_2$. The cell viability and apoptosis were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry analysis, respectively. The levels of reactive oxygen species (ROS), mitochondrial membrane potentials (MMPs) and adenosine tri-phosphate (ATP) contents were measured. Expression levels of Bcl-2 and Bax were also determined using Western blot analysis. Results: The results showed that the decreased survival rate induced by $H_2O_2$ could be attributed to the induction of DNA damage and apoptosis accompanied by the increased production of ROS, which was remarkably protected by EEPR. In addition, the loss of $H_2O_2$-induced MMPs and ATP contents was significantly attenuated in the presence of EEPR. The inhibitory effect of EEPR on $H_2O_2$-induced apoptosis was associated with up-regulation of Bcl-2 and down-regulation of Bax, thus reducing the Bax/Bcl-2 ratio. Conclusions: Our data prove that EEPR protects Chang liver cells against $H_2O_2$-induced DNA damage and apoptosis by scavenging ROS and thus suppressing the mitochondrial-dependent apoptosis pathway.
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참고문헌 (44)
참고문헌 신청
Brian H. May / 2013 / Chinese Herbs for Memory Disorders: A Review and Systematic Analysis of Classical Herbal Literature / Journal of Acupuncture & Meridian Studies 6(1):2~11
Cao Q / 2016 / Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice / Phytomedicine 23(14):1797~1805
Kim KS / 2013 / The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect / Eur J Pharmacol 721(1-3):267~276
Sun XL / 2007 / Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task / Biol Pharm Bull 30(9):1727~1731
Kawashima K / 2004 / Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji) / Biol Pharm Bull 27(8):1317~1319
Cao Q / 2016 / Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice / Phytomedicine 23(14):1797~1805
Kim KS / 2013 / The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect / Eur J Pharmacol 721(1-3):267~276
Sun XL / 2007 / Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task / Biol Pharm Bull 30(9):1727~1731
Kawashima K / 2004 / Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji) / Biol Pharm Bull 27(8):1317~1319
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