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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 7 - 14 (8page)
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Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the effect of vinpocetine on the proliferation of colon cancer cells and its underlying molecular mechanisms. Our data showed that vinpocetine inhibits the viability and proliferation of colon cancer cells. Vinpocetine treatment induced cell death in HCT116 cells, which the percentages of sub-G1 phase were significantly increased, and the apoptosis-related genes were regulated after HCT116 cells were treated with vinpocetine. In sum, our findings indicated that vinpocetine could be a therapeutically useful candidate in the treatment of colon cancer.
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참고문헌 (30)
참고문헌 신청
Iqbal S / 2004 / Integration of novel agents in the treatment of colorectal cancer / Cancer Chemother Pharmacol 54(Suppl 1):S32~S39
Zhang YS / 2018 / An update on vinpocetine : new discoveries and clinical implications / Eur J Pharmacol 819:30~34
Patyar S / 2011 / Role of vinpocetine in cerebrovascular diseases / Pharmacol Rep 63:618~628
Dézsi L / 2002 / Neuroprotective effects of vinpocetine in vivo and in vitro. Apovincaminic acid derivatives as potential therapeutic tools in ischemic stroke / Acta Pharm Hung 72:84~91
Szilágyi G / 2005 / Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients : a PET study / J Neurol Sci 229-230:275~284
Zhang YS / 2018 / An update on vinpocetine : new discoveries and clinical implications / Eur J Pharmacol 819:30~34
Patyar S / 2011 / Role of vinpocetine in cerebrovascular diseases / Pharmacol Rep 63:618~628
Dézsi L / 2002 / Neuroprotective effects of vinpocetine in vivo and in vitro. Apovincaminic acid derivatives as potential therapeutic tools in ischemic stroke / Acta Pharm Hung 72:84~91
Szilágyi G / 2005 / Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients : a PET study / J Neurol Sci 229-230:275~284
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